Results 51 to 60 of about 1,371,376 (301)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

All-optical 160 Gbit/s retiming system using fiber grating based pulse shaping technology [PDF]

, 2009
This paper demonstrates a retiming system operating at rates of 40 and 160 Gbit/s, which incorporates a superstructured fiber Bragg grating (SSFBG) as a pulse shaping element.
Galili, Michael, Ibsen, M., Petropoulos, P., Ibsen, Morten, Richardson, D.J., Richardson, David J., Zibar, Darko, Parmigiani, Francesca, Clausen, Anders, Petropoulos, Periklis, Oxenløwe, Leif Katsuo, Parmigiani, F., Clausen, Anders Thomas, Jeppesen, Palle, David J. Richardson, Darko Zibar, Francesca Parmigiani, Palle Jeppesen, Morten Ibsen, Periklis Petropoulos, Michael Galili, Leif Katsuo Oxenlowe, Anders Thomas Clausen   +22 more
core   +2 more sources

Real-space observation of the dissociation of a transition metal complex and its concurrent energy redistribution

Nature Communications
Mechanistic insights into photodissociation dynamics of transition metal carbonyls, like Fe(CO)5, are fundamental for understanding active catalytic intermediates.
Aviad Schori, Elisa Biasin, Ambar Banerjee, Sébastien Boutet, Philip H. Bucksbaum, Sergio Carbajo, Kelly J. Gaffney, James M. Glownia, Robert Hartsock, Kathryn Ledbetter, Andreas Kaldun, Jason E. Koglin, Kristjan Kunnus, Thomas J. Lane, Mengning Liang, Michael P. Minitti, Jordan T. O’Neal, Robert M. Parrish, Frédéric Poitevin, Jennifer M. Ruddock, Silke Nelson, Brian Stankus, Peter M. Weber, Thomas J. A. Wolf, Michael Odelius, Adi Natan   +25 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

CURRENT STATE AND PERSPECTIVES OF DEVELOPMENT OF DESIGN OF ELECTRIC DISCHARGE SUBMERSIBLE DEVICES FOR TREATMENT OF WELLS

Elektrotehnìka ta Elektroenergetika, 2019
Purpose. Assessment of the current state, design features and development prospects of electric-discharge submersible devices for well treatment. Methodology. Analysis of the principle of operation and design of electric-discharge submersible devices for
O.V. Khvoshchan, V.G. Zhekul, A.P. Smirnov   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

kotik-coder/PULsE: PULsE v1.93F : fixes

, 2021
Full Changelog: https://github.com/kotik-coder/PULsE/compare/v1.93...v1 ...
Artem Lunev
core   +1 more source

Dual-pulse laser induced breakdown spectroscopy in the vacuum ultraviolet with ambient gas: spectroscopic analysis and optimization of limit of detection of carbon and sulfur in steel [PDF]

, 2012
Laser Induced Breakdown Spectroscopy (LIBS) in the vacuum ultraviolet (VUV) spectral region was applied to standard steel samples in dual-pulse excitation mode with an ambient gas. Two lasers were employed in collinear geometry, one as an ablation laser (
Jiang, Xi
core   +2 more sources