Results 61 to 70 of about 2,704,319 (347)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Logic circuit detects both present and missing negative pulses in superimposed wave trains [PDF]

open access: yes, 1967
Pulse divide and determination network provides a logical determination of pulse presence within a data train. The network uses digital logic circuitry to divide positive and negative pulses, to shape the separated pulses, and to determine, by means of ...
Rice, R. E.
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Explosion crushing of scrap-iron and wastes

open access: yesЛитьë и металлургия, 2001
The article is devoted to primary processing of ferrous and non-ferrous metals with explosion power.
A. A. Andrushevich   +2 more
doaj  

Laboratory pulse modulator uses minority carrier storage diodes [PDF]

open access: yes, 1967
Pulse modulator is capable of continuously variable pulse width over a 10 to 1 range of 1.0 microsecond to 0.1 microsecond and operates over a wide range of pulse repetition rates.

core   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

open access: yesFEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová   +11 more
wiley   +1 more source

Application of impulse methods of weighting in the refractory capsules production process

open access: yesЛитьë и металлургия, 2000
The article is devoted to the problem of manufacture of refractoty capsules of increased endurance out of difficult-to-extrude alloy powders made by impulse action method.
V. T. Shmuradko   +2 more
doaj  

Probing ultrafast ππ*/nπ* internal conversion in organic chromophores via K-edge resonant absorption

open access: yesNature Communications, 2017
Many photo-induced processes such as photosynthesis occur in organic molecules, but their femtosecond excited-state dynamics are difficult to track. Here, the authors exploit the element and site selectivity of soft X-ray absorption to sensitively follow
T. J. A. Wolf   +23 more
doaj   +1 more source

Reaching the highest shelf: A review of organic production, nutritional quality, and shelf life of kale (Brassica oleracea var. acephala)

open access: yesPlants, People, Planet, 2021
Societal Impact Statement Since its inception in the early 20th century, organic agriculture has grown increasingly popular due to its focus on a holistic, environmentally friendly approach to crop production.
Tony Reda   +5 more
doaj   +1 more source

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