Results 71 to 80 of about 4,099,910 (388)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Explosion crushing of scrap-iron and wastes
Литьë и металлургия, 2001 The article is devoted to primary processing of ferrous and non-ferrous metals with explosion power.
A. A. Andrushevich +2 more
doaj
Short wind pulses consistently change the morphology of roots, but not of shoots, across young plants of different growth forms [PDF]
, 2023 Johannes Heinze +5 more
openalex +1 more source
Logic circuit detects both present and missing negative pulses in superimposed wave trains [PDF]
, 1967 Pulse divide and determination network provides a logical determination of pulse presence within a data train. The network uses digital logic circuitry to divide positive and negative pulses, to shape the separated pulses, and to determine, by means of ...
Rice, R. E.
core +1 more source
Pulsed quantum optomechanics [PDF]
Proceedings of the National Academy of Sciences, 2011 Studying mechanical resonators via radiation pressure offers a rich avenue for the exploration of quantum mechanical behavior in a macroscopic regime. However, quantum state preparation and especially quantum state reconstruction of mechanical oscillators remains a significant challenge.
Vanner, M. R. +7 more
openaire +6 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Application of impulse methods of weighting in the refractory capsules production process
Литьë и металлургия, 2000 The article is devoted to the problem of manufacture of refractoty capsules of increased endurance out of difficult-to-extrude alloy powders made by impulse action method.
V. T. Shmuradko +2 more
doaj
Probing ultrafast ππ*/nπ* internal conversion in organic chromophores via K-edge resonant absorption
Nature Communications, 2017 Many photo-induced processes such as photosynthesis occur in organic molecules, but their femtosecond excited-state dynamics are difficult to track. Here, the authors exploit the element and site selectivity of soft X-ray absorption to sensitively follow
T. J. A. Wolf +23 more
doaj +1 more source
Ultrastable reference pulser for high-resolution spectrometers [PDF]
, 1970 Solid-state double-pulse generator for a high resolution semiconductor detector meets specific requirements for resolution /0.05 percent/, amplitude range /0.1-13 MeV/, and repetition rate /0.1-1000 pulses per second/.
Brenner, R. +3 more
core +1 more source