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Complexity and Perplexity of Pulsed Field Ablation: An Engineering Perspective. [PDF]

Arrhythm Electrophysiol Rev
Kos B, Reberšek M, Miklavčič D.
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Hemolysis after pulsed-field ablation in pulmonary vein isolation for atrial fibrillation: A prospective controlled trial

Heart Rhythm
BACKGROUND Intravascular hemolysis with consecutive acute kidney injury (AKI) has been described after pulsed field ablation (PFA) in atrial fibrillation (AF).
Carsten Auf der Heiden, Alexandru Bejinariu   +1 more
exaly   +2 more sources

Characterization and Clinical Significance of Hemolysis After Pulsed Field Ablation for Atrial Fibrillation: Results of a Multicenter Analysis

Circulation: Arrhythmia and Electrophysiology
BACKGROUND: Pulsed field ablation (PFA) is increasingly used in clinical practice for the treatment of atrial fibrillation. While the susceptibility of erythrocytes to electroporation is well established, the effect of cardiac PFA technologies on ...
Miruna Popa, Roberto Mene, Domenico G Della Rocca   +2 more
exaly   +2 more sources

Pulsed Field Ablation: A Comprehensive Update

Journal of Clinical Medicine
One of the recent advancements in the field of cardiac electrophysiology is pulsed field ablation (PFA). PFA is a novel energy modality that does not rely on thermal processes to achieve ablation which, in turn, results in limited collateral damage to surrounding structures.
Fatima M Ezzeddine, , Ezzeddine Fatima M
exaly   +3 more sources

Pulsed Field Ablation: a New Paradigm for Catheter Ablation of Arrhythmias

Current Cardiology Reports, 2022
Current ablation approach for arrhythmias relies upon the use of radiofrequency (RF) and cryoablation catheters. Although there have been significant advances both in catheter design and in energy delivery approaches, limitations such as suboptimal efficacy and safety remain.
Abhishek, Maan, Jacob, Koruth
openaire   +2 more sources

Pulsed Field Ablation of Persistent Atrial Fibrillation With Continuous Electrocardiographic Monitoring Follow-Up: ADVANTAGE AF Phase 2

Circulation
BACKGROUND: There are sparse high-quality safety and effectiveness data for pulsed field ablation (PFA) of persistent atrial fibrillation (PerAF), in which lesions beyond pulmonary vein isolation (PVI) are often placed.
Vivek Y. Reddy, Edward P. Gerstenfeld, Boris Schmidt, J. Andrade, D. Nair, Andrea Natale, W. Saliba, P. Sommer, A. Metzner, A. Verma, T. Hounshell, Anish K Amin, Philip Gentlesk, S. Weiner, Frank Cuoco, Jamie Kim, M. Turagam, G. Tomassoni, Chinmay Patel, Ziad Issa, Michael Shehata, A. Anderson, Thomas J. Stoltz, Jonathan D. Raybuck, Torri Schwartz, B. Sutton, M. Mansour   +26 more
semanticscholar   +1 more source

Repeat procedures after pulsed field ablation for atrial fibrillation: MANIFEST-REDO study

Europace
Aims Initial clinical studies of pulsed field ablation (PFA) to treat atrial fibrillation (AF) indicated a >90% durability rate of pulmonary vein isolation (PVI).
D. Scherr, M. Turagam, Philippe Maury, Y. Blaauw, P. van der Voort, Petr Neužil, T. Reichlin, A. Metzner, J. Vijgen, J. Kautzner, S. Boveda, A. Anić, J. Hansen, M. Manninger, P. Sommer, F. Anselme, S. Willems, T. Deneke, R. Tilz, Daniel Steven, Reza Wakili, P. Jais, M. Funasako, T. Arentz, A. Rollin, B. A. Mulder, A. Ouss, J. Petru, Thomas Kueffer, M. Lemoine, P. Koopman, P. Peichl, R. Adeliño, Z. Jurišić, M. Ruwald, Anna-Sophie Eberl, C. Sohns, A. Savouré, K. Nentwich, M. Gunawardene, Christian-Hendrick Heeger, Arian Sultan, J. Bohnen, J. Kupusovic, N. Derval, H. Lehrmann, E. Ekanem, Vivek Y. Reddy   +47 more
semanticscholar   +1 more source

NEMESIS-PFA: Investigating Collateral Tissue Injury Associated with Pulsed Field Ablation.

JACC Clinical Electrophysiology
BACKGROUND Early evidence showed reduced complications with pulsed field ablation (PFA), but non-target tissue collateral damage created by electroporation effects is poorly understood and may significantly differ between systems.
D. Lakkireddy, Aashish Katapadi, J. Garg, E. Herink, Michael Klotz, Jagruth Ghanta, Aanya Kabra, Rajesh Kabra, N. Pothineni, D. Darden, R. Tummala, S. Koerber, R. Gopinathannair, Sudharani Bommana, D. Atkins, Rahul Chaudhary, M. Mbai, Venkat Tholakanahalli, S. Mohanty, L. DiBiase, Andrea Natale   +20 more
semanticscholar   +1 more source

Safety and effectiveness of the first balloon-in-basket pulsed field ablation system for the treatment of atrial fibrillation: VOLT CE Mark Study 6-month results

Europace
Aims Pulsed field ablation (PFA) is a growing ablation modality for pulmonary vein isolation (PVI) in atrial fibrillation (AF) patients. This study assesses the 6-month safety and effectiveness of a novel balloon-in-basket, mapping-integrated PFA system,
R. Tilz, G. Chierchia, M. Gunawardene, Prashanthan Sanders, Haris M. Haqqani, Jonathan M. Kalman, S. Healy, H. Puererfellner, Petr Neužil, J. Osca Asensi, P. Loh, Vivek Y. Reddy, S. Knecht, E. Jesser, N. Dirckx, Amber Miller, D. Walker, Dhanunjaya Lakkireddy   +17 more
semanticscholar   +1 more source

Pulsed field ablation for atrial fibrillation

Expert Review of Medical Devices
Atrial fibrillation is the most common sustained arrhythmia, associated with substantial morbidity and a reduced quality of life. The current standard of care, transcatheter pulmonary vein isolation using thermal ablation techniques, provides symptom relief but carries a risk of collateral tissue damage.
Vedran Pašara, Tommaso Sattin, Carlo De Asmundis, Gian-Battista Chierchia, Gezim Bala   +4 more
openaire   +3 more sources