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Pulsed field ablation: a promise that came true

Current Opinion in Cardiology, 2021
Purpose of review Pulsed field ablation is a nonthermal ablative modality that uses short living, strong electrical field created around catheter to create microscopic pores in cell membranes (electroporation). When adequately dosed/configured it shows a preference for myocardial tissue necrosis.
Ante, Anic   +2 more
openaire   +2 more sources

Real-world experience with the pentaspline pulsed field ablation system: one-year outcomes of the FARADISE registry

Europace
Aims Clinical studies with protocol-mandated workflow and monitoring have analysed performance of pulsed field ablation (PFA) for treating atrial fibrillation (AF).
L. Boersma   +26 more
semanticscholar   +1 more source

Biophysics of Electroporation and Pulsed Field Ablation

Cardiac Electrophysiology Clinics
High-voltage electric fields can lead to increased permeability of cell membranes-a phenomenon called electropermeabilization. The mechanisms contributing to this effect are electroporation, membrane lipid peroxidation, oxidative stress, and structural changes in membrane proteins.
Moritz, Nies, Jacob S, Koruth
openaire   +2 more sources

Feasibility and mid-term effectiveness of focal pulsed field ablation for ventricular arrhythmias.

Heart Rhythm
BACKGROUND Pulsed field ablation (PFA) is a promising novel method of atrial ablation with preclinical data suggesting it to be a viable option for ventricular arrhythmias.
M. Ruwald   +5 more
semanticscholar   +1 more source

Lesion Characteristics of Pulsed Field Ablation

Cardiac Electrophysiology Clinics
Pulsed field ablation (PFA) has emerged as a promising, nonthermal technique for arrhythmia ablation, leveraging high-voltage electrical fields to induce electroporation and create precise ablation lesions. Unlike traditional thermal methods such as radiofrequency ablation (RFA) and cryoablation, PFA selectively targets myocardial cells while sparing ...
Charbel, Noujaim   +3 more
openaire   +2 more sources

Early versus late atrial fibrillation recurrence after pulsed field ablation: insights from the admIRE trial

Europace
Aims Studies have shown correlations between early recurrence (ER) and late recurrence (LR) of atrial arrhythmia after ablation with thermal technologies. This admIRE trial (NCT05293639) subanalysis aims to analyse ER vs.
L. di Biase   +13 more
semanticscholar   +1 more source

Irrigation of Pulsed Field Ablation Electrodes Mitigates Joule Heating and Heat Stacking Phenomena.

JACC Clinical Electrophysiology
Pulsed field ablation (PFA) has emerged as a non-thermal method for cardiac ablation for the treatment of arrhythmias. Several packets of high-voltage biphasic pulses result in the irreversible electroporation of targeted myocytes, rendering the tissue ...
William H. Sauer   +2 more
semanticscholar   +1 more source

2025 International Expert Practical Guide on the Use of the Pentaspline Pulsed Field Ablation System in Atrial Fibrillation Ablation Procedures

Circulation: Arrhythmia and Electrophysiology
Pulsed field ablation (PFA) has been developed as a largely nonthermal ablation technology with a unique biophysical profile to treat atrial fibrillation.
Shaojie Chen   +22 more
semanticscholar   +1 more source

„Pulsed field ablation“

Herzschrittmachertherapie + Elektrophysiologie, 2022
Nico Reinsch   +3 more
openaire   +1 more source

Catheters and Tools with Pulsed Field Ablation—Pulmonary Vein Isolation and Nanosecond Pulse Field Ablation

Cardiac Electrophysiology Clinics
Pulse field ablation (PFA) has gained attention in the field of atrial fibrillation catheter treatment recently. All currently used or developed technologies use ultrashort pulses (on the order of microseconds). The Emerging CellFX System (Pulse Biosciences, Inc, Inc) utilizes nanosecond PFA (nsPFA) and is thus several orders of magnitude shorter than ...
Jan, Petru   +2 more
openaire   +2 more sources

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