Results 111 to 120 of about 41,948 (183)

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Characteristics of vancomycin-resistant enterococci (VRE) isolated from medical fields in Japan [PDF]

, 2018
学位記番号 ...
Hashimoto, Yusuke, ハシモト, ユウスケ, 橋本, 佑輔   +2 more
core  

Safe and Efficient CRISPR Genome Editing of Primary Human T Cells Using a Droplet‐Based Cell Mechanoporation Platform

Small, EarlyView.
This study introduces a microfluidic droplet mechanoporation system for the engineering of primary human T cells. The platform enables efficient, scalable, and robust delivery of mRNA for CAR T cell production and CRISPR‐Cas9 ribonucleoproteins for genome editing, while maintaining high cell viability.
You‐Jeong Kim, Sungwon Bang, Aram J. Chung   +2 more
wiley   +1 more source

Importance of hydrodynamic shielding for the dynamic behavior of short polyelectrolyte chains

, 2008
The dynamic behavior of polyelectrolyte chains in the oligomer range is investigated with coarse-grained molecular dynamics simulation and compared to data obtained by two different experimental methods, namely capillary electrophoresis and ...
Böhme, Ute, Cottet, Hervé, Grass, Kai, Holm, Christian, Scheler, Ulrich   +4 more
core   +1 more source

Compostable and Recyclable Baroplastic Triblock Copolymers Enable Low‐Energy Polymer Processing

Small, EarlyView.
Baroplastic Poly(L‐lactide)‐block‐poly(ethylene glycol)‐block‐poly(L‐lactide) triblock copolymers enable ambient‐temperature processing under moderate pressure, reducing energy demand while preserving polymer integrity. The materials show rapid industrial compostability, effective chemical and physical recyclability, and compatibility with heat ...
Chengzhang Xu, Chengwei Yi, Emilia Fulajtar, Anja FRM Ramsperger, Julian Brehm, Christian Laforsch, Holger Schmalz, Sabine Rosenfeldt, Ulrich Mansfeld, Holger Kress, Andreas Möglich, Andreas Greiner, Seema Agarwal   +12 more
wiley   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Genotyping of Salmonella Enterica Serovar Enteritidis Strains Isolated from Clinical Samples by Pulsed-Field Gel Electrophoresis (PFGE)

مجله دانشکده پزشکی اصفهان, 2013
Background: The infections caused by Salmonella enterica serovar enteritidis (Salmonella enteritidis) have been increasing in developed and developing countries.
Zeinab Ahmadi, Reza Ranjbar, Meysam Sarshar   +2 more
doaj  

Review on the development of truly portable and in-situ capillary electrophoresis systems

, 2013
Capillary electrophoresis (CE) is a technique which uses an electric field to separate a mixed sample into its constituents. Portable CE systems enable this powerful analysis technique to be used in the field.
Cranny, Andy, Green, Nicolas G, Harris, Nick, Lewis, Adam, Stokes, Keith R., Wharton, Julian A., Wood, R.J.K.   +6 more
core   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, EarlyView.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source