Results 111 to 120 of about 28,540 (263)

Navigating Evidence Standards: Stakeholder Perspectives on External Controls and Randomization in Cancer Trials

Asia-Pacific Journal of Clinical Oncology, EarlyView.
While historically the ‘gold standard,’ the role of large‐scale RCTs is being increasingly challenged in the contemporary oncology research era. External controls represent an alternate method for generating evidence, though the perspectives of key stakeholders regarding their role in oncology are not well known.
Sarah E. Heynemann, Wendy L. Lipworth, Sue‐Anne McLachlan, Jennifer Philip, Tom John, Ian H. Kerridge   +5 more
wiley   +1 more source

Revisión de representaciones de felinos (Felidae: Carnívora) en piezas arqueológicas y en toponimia alusiva de El Salvador

Revista Minerva
Se realizó revisión bibliográfica de libros (cuatro), artículos científicos (tres) y visitas a un sitio arqueológico (Casa Blanca) y MUNA. Como producto de este proceso se obtuvo datos de representaciones de individuos de la familia Felidae Orden ...
Ricardo Ibarra Portillo
doaj   +1 more source

Pulmonary artery catheters or central venous catheters for cardiac surgery: the PUMA Pilot randomised clinical trial

Anaesthesia, EarlyView.
Summary Introduction Pulmonary artery catheters are used widely in cardiac surgery despite observed associations with worse outcomes and guidelines that recommend against their routine use. No adequately powered randomised trials are available. Methods The PUMA Pilot was a multicentre, randomised, parallel assignment, open‐label, pilot and feasibility ...
Luke A. Perry, Reny Segal, Marco Larobina, Rinaldo Bellomo, Julian A. Smith, Jesselyn Sin, Katrina Danial, Alistair R. D. McLean, Lisa Q. Rong, Mario Gaudino, Thomas Schwann, Marie Palumbo, Luke O'Halloran, Brian Chee, Jinesh Patel, Andrew Silvers, Jayme Bennetts, Silvana Marasco, Tim G. Coulson, Alistair Royse, Emily See, Lachlan F. Miles, on behalf of the ANZCA Clinical Trials Network   +22 more
wiley   +1 more source

Talc‐Tempered Pottery From Bala Hissar, Kabul: An Analytical Study

Archaeometry, EarlyView.
ABSTRACT Potsherds of cooking ware excavated at Bala Hissar archaeological site in Kabul were studied using X‐ray fluorescence (XRF), scanning electron microscope‐energy dispersive X‐ray spectrometry (SEM‐EDS), Raman spectroscopy, X‐ray powder diffraction (XRPD), thermogravimetric analysis (TGA) and optical microscopy.
Parviz Holakooei, Babak Rafiei‐Alavi, Hafizullah Hazim, Hasti Pezeshkanjalili, Lara Maritan   +4 more
wiley   +1 more source

El jabalí europeo (Sus scrofa): Un invasor biológico como presa reciente del puma (Puma concolor) en el sur de Chile The European wild boar (Sus scrofa): A biological invader as a recent prey of the American puma (Puma concolor) in southern Chile

Revista Chilena de Historia Natural, 2012
Se estudió la dieta del puma (Puma concolor)en los anos 1988 y 2004 en los faldeos de los volcanes Mocho y Choshuenco, pluviselva valdiviana, sur de Chile, a través de la identificación de ítemes-presas en sus heces y la búsqueda en terreno de carcasas ...
OSCAR SKEWES, CLAUDIO A MORAGA, PATRICIO ARRIAGADA, JAIME R RAU   +3 more
doaj  

Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment‐related pathways

British Journal of Haematology, EarlyView.
Selinexor targets molecular pathways critical to myelofibrosis (MF) progenitor cell fitness and demonstrates complementary activity with ruxolitinib, supporting its potential as a novel disease‐modifying therapeutic strategy for MF. Summary Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional ...
Trinayan Kashyap, Andrea A. Ellero, Christopher J. Walker, Marie E. Maloof, Min Lu, Lijuan Xia, Ronald Hoffman, Pietro Taverna   +7 more
wiley   +1 more source

A Ch'ixi Philosophy of History: Rivera Cusicanqui After Benjamin

Constellations, EarlyView.
Daniel Luna Jacobs
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Ezh2 Inhibits the Differentiation of Short‐Lived Effector CD8+ T Cells and Promotes T Cell‐Dependent Antitumor Immunity

Cancer Science, EarlyView.
The antitumor immune response is attenuated in T cell‐specific Ezh2 knockout mice. ABSTRACT Appropriate regulation of the differentiation balance between effector CD8+ T cells and memory CD8+ T cells is crucial for an appropriate immune response. We previously reported that the tumor suppressor menin suppresses the differentiation of CD8+ T cells into ...
Kenji Takagi, Junpei Suzuki, Yuko Matsuoka, Makoto Kuwahara, Taro Oshikiri, Masakatsu Yamashita   +5 more
wiley   +1 more source

Psychometric framework for coexistence with large carnivores

Conservation Biology, EarlyView.
Abstract Human–carnivore coexistence is essential for biodiversity conservation, yet measuring the attitudes and behaviors that support it remains methodologically challenging. We developed psychometric scales to assess willingness to coexist with carnivores and the underlying beliefs of this coexistence through an iterative expert elicitation process ...
Benjamin Ghasemi, Gerard Kyle, Tara Teel, Rebeca Niemiec, Kevin Crooks, Jenny Anne Glikman, Neil H. Carter, John A. Vucetich, Michelle L. Lute, Stewart Breck, Beatrice Frank, Dana Hoag, Jonathan Salerno, Lily M. van Eeden, Jeremy T. Bruskotter   +14 more
wiley   +1 more source