Results 131 to 140 of about 27,668 (261)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, Volume 20, Issue 3, Page 637-667, March 2026.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Trophic Duality: Taxonomic Segregation and Convergence in Prey Functional Traits Driving the Coexistence of Apex Predators. [PDF]

Biology (Basel)
Entringer H, Srbek-Araujo AC.
europepmc   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism. [PDF]

Nat Commun
Maillet L, Fétiveau A, Lalier L, Martin N, Barillé-Nion S, Guette C, Gautier F, Téletchéa S, Juin PP.   +8 more
europepmc   +1 more source

Dual‐Target ROS‐Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We developed a senolytic approach using procyanidin C1 (PCC1)‐loaded platform, a clinically established and safe hyaluronic acid‐based scaffold, to selectively eliminate senescent endothelial and microglial cells. This dual‐targeting strategy significantly suppresses pathological neovascularization and promotes vascular repair, presenting a safe and ...
Yali Zhou, Tianxing Chen, Peiyu Liu, Kangjia Lv, Yifan Wang, Xiaoqian Wang, Junwei Fang, Chong Chen, Zhaoyang Wang, Fang Wei, Xun Xu   +10 more
wiley   +1 more source

Review of Memristors for In‐Memory Computing and Spiking Neural Networks

Advanced Intelligent Systems, Volume 8, Issue 3, March 2026.
Memristors uniquely enable energy‐efficient, brain‐inspired computing by acting as both memory and synaptic elements. This review highlights their physical mechanisms, integration in crossbar arrays, and role in spiking neural networks. Key challenges, including variability, relaxation, and stochastic switching, are discussed, alongside emerging ...
Mostafa Shooshtari, Teresa Serrano‐Gotarredona, Bernabé Linares‐Barranco   +2 more
wiley   +1 more source

Testicular degeneration in a jaguarundi (Puma yagouaroundi): a histological and functional case study. [PDF]

Vet Res Commun
Pinzón-Osorio CA, Cortes-Beltran D, Bellido-Quispe DK, Mondadori RG, Lozano-Márquez H, Zambrano-Varón J, Jiménez-Escobar C.   +6 more
europepmc   +1 more source

Multiomic characterization of small cell lung cancer: Real‐world insights into therapeutic opportunities

Cancer, Volume 132, Issue 5, 1 March 2026.
NK, natural killer; STING, Stimulator of Interferon Genes; TCI, T‐cell inflamed. Abstract Background The dominant expression of lineage‐related transcription factors (TFs)—ASCL1, NEUROD1, POU2F3, and, controversially, YAP1—has enabled the classification of small cell lung cancer (SCLC) into distinct subtypes (SCLC‐A/N/P/Y, respectively).
Sonam Puri, Andrew Elliott, Abdul Rafeh Naqash, Hassan Abu Shukair, Kathleen C. Kerrigan, Shiven Patel, Andreas Seeber, Florian Kocher, Dipesh Uprety, Hirva Mamdani, Amit A. Kulkarni, Gilberto Lopes, Balazs Halmos, Hossein Borghaei, Wallace Akerley, Gabriel L. Sica, Stephen V. Liu, Trudy G. Oliver, Taofeek K. Owonikoko   +18 more
wiley   +1 more source

NDRG2 upregulation induces astrocytic apoptosis via AKT inhibition and FoxO3a-Puma activation in depression. [PDF]

Commun Biol
Wang Z, Yang J, Zhang H, Ke D, Zhang L, Liu Y, Lai Y, Zhang Y, Qin X, Yang J, Kang M, Yang W, Wang X, Zeng J, Liu R.   +14 more
europepmc   +1 more source

From Compliance to Collaboration: Towards a Strategic Framework for Social Sustainability in Fashion Supply Chains—Insights From a Two‐Phase Literature Review

Corporate Social Responsibility and Environmental Management, Volume 33, Issue 2, Page 2783-2801, March 2026.
ABSTRACT The purpose of this study is to provide a comprehensive longitudinal analysis of the evolution of social sustainability within the global textile and fashion industry across two distinct regulatory eras: post‐Multifibre Agreement (2005–2018) and post‐Modern Slavery Act (2019–2023).
Amanpreet Singh, Alice Ruth Payne, Rudrajeet Pal   +2 more
wiley   +1 more source