Editorial Note: The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. [PDF]
PLOS One Editors.
europepmc +1 more source
What's new? CATCH is a prospective precision oncology registry trial that harnesses whole‐genome/exome‐ and RNA‐sequencing to enable actionable biomarker detection in metastatic breast cancer patients of any subtype. The data of the first 412 consecutive patients with completed follow‐up in this real‐world, single‐center patient cohort provide robust ...
Mario Hlevnjak +31 more
wiley +1 more source
The multifaceted role of PUMA in cell death pathways: its therapeutic potential across cancer types. [PDF]
Tat SS +6 more
europepmc +1 more source
“You Are Safe Now”: Migrant Youth Constructions of Safety and Schooling in the U.S.
ABSTRACT Drawing on multisited ethnographic research with migrant families from Brazil, El Salvador, Guatemala, and Honduras who were detained, separated, or endured prolonged transit due to US immigration policies, we articulate how ideas of “relational safety” are situated in relationships with people, place, and time. Contrasting abundant literature
Michelle J. Bellino, Gabrielle Oliveira
wiley +1 more source
PUMA-p53 Dysregulation and Ki-67 Overexpression Define Unfavorable Prognostic Signatures in Colorectal Cancer. [PDF]
Mekras A +6 more
europepmc +1 more source
We report the first confirmed record of an ocelot (Leopardus pardalis) dragging a newborn calf in a degraded forest fragment of southeastern Brazil. Using camera trap records, we reveal an opportunistic foraging event involving a vulnerable domestic prey within a highly fragmented landscape.
Álvaro Augusto Naves Silva +2 more
wiley +1 more source
ABSTRACT Pastoralism worldwide faces a complex landscape of increased pressures and exclusion. Beyond ecological and economic challenges, pastoralists suffer eroding cultural identity, limited generational renewal, and political marginalization. Yet pastoral livelihoods are increasingly recognized as stewards of sustainable futures and amongst the best
Greta Semplici, Pablo Manzano
wiley +1 more source
Integrated transcriptomic analysis and experimental validation identify ACADL as a mitochondrial tumor suppressor via the FOXO3a/PUMA axis in lung adenocarcinoma. [PDF]
Wang Y, Ding Y.
europepmc +1 more source
Scat DNA Applications for Low‐Density Carnivore Survey: Techniques, Efficiency and Future Directions
We reviewed 338 studies encompassing mostly Felidae, Canidae and Mustelidae species throughout the world, confirming scat DNA as a reliable genetic source for many applications. The findings here offer guidance for future studies on low‐density carnivores, helping to design cost‐effective research and improving data quality for conservation efforts ...
Marina Elisa de Oliveira +2 more
wiley +1 more source
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer. [PDF]
Jia G +11 more
europepmc +1 more source

