Results 111 to 120 of about 129,066 (229)

Ultrafast All‐Optical Switching and Active Sub‐Cycle Waveform Control via Time‐Variant Photodoping of Terahertz Metasurfaces

Advanced Science
The development of high‐speed and high‐performance optical switches has been a long‐standing issue in the field of photonics. This paper introduces a pioneering time‐resolved spectroscopy‐based approach for realizing photon‐induced ultrafast terahertz ...
Jeongmin Jang, Junsuk Rho, Hee Jun Shin
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Ultrafast photoelectron spectroscopy of solutions: space-charge effect

New Journal of Physics, 2015
The method of time-resolved XUV photoelectron spectroscopy is applied in a pump–probe experiment on a liquid micro-jet. We investigate how the XUV energy spectra of photoelectrons are influenced by the space charge created due to ionization of the liquid
R Al-Obaidi, M Wilke, M Borgwardt, J Metje, A Moguilevski, N Engel, D Tolksdorf, A Raheem, T Kampen, S Mähl, I Yu Kiyan, E F Aziz   +11 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Design and develop an optical setup related to the pump-probe technique for spectroscopic study

مجلة بغداد للعلوم
In this research, an optical system using Pump-Probe technology was designed to study the effect of changing the Frequency values, integration time, delay time, and laser pulse width on the pumping pulse energy on an arbitrary laser dye material with an
Saad Kh. Rahi Rahi, Muayyed J. Zoory Zoory, Alaa H. Ali   +2 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Ultrafast response of photoexcited carriers in VO2 at high-pressure

New Journal of Physics, 2018
We utilize near-infrared pump—mid-infrared probe spectroscopy to investigate the ultrafast electronic response of pressurized VO _2 . A clear anomaly in the linear mid-infrared response as well as in the fluence dependence of the pump–probe signal is ...
Johannes M Braun, Harald Schneider, Manfred Helm, Rafał Mirek, Lynn A Boatner, Robert E Marvel, Richard F Haglund Jr, Alexej Pashkin   +7 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source