Results 71 to 80 of about 1,388,178 (317)

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

eLife, 2017
Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope.
Zhao Wang, G. Fan, C. Hryc, JN Blaza, I. Serysheva, M. Schmid, W. Chiu, B. Luisi, D. Du   +8 more
semanticscholar   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Underwater Targets Radiated Noise Classification Based on Enhanced Images and Convolutional Neural Networks

IEEE Access
As the economy and society continue to develop, the types of underwater targets are becoming increasingly diverse, accompanied by a corresponding increase in environmental noise.
Lei Zhufeng, Luo Jiachao, Qin Qiwei, Lei Xiaofang, Zhou Chuanghui, Zhang Qian   +5 more
doaj   +1 more source

In situ structure and assembly of the multidrug efflux pump AcrAB-TolC

Nature Communications, 2019
Multidrug efflux pumps actively expel a wide range of toxic substrates from the cell and play a major role in intrinsic and acquired drug resistance. In Gram-negative bacteria, these pumps form tripartite assemblies that span the cell envelope.
Xiaodong Shi, Muyuan Chen, Zhili Yu, James M. Bell, Hanson Wang, Isaac Forrester, Heather Villarreal, J. Jakana, D. Du, B. Luisi, S. Ludtke, Zhao Wang   +11 more
semanticscholar   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Comparative Genomics of Environmental and Clinical Burkholderia cenocepacia Strains Closely Related to the Highly Transmissible Epidemic ET12 Lineage

Frontiers in Microbiology, 2018
The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage.
Josselin Bodilis, Josselin Bodilis, Elodie Denet, Elisabeth Brothier, Arnault Graindorge, Sabine Favre-Bonté, Sylvie Nazaret   +6 more
doaj   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso‐Occlusive Pain Episodes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman, Maria Yasmine, Dunia Hatabah, Noor Alzraikat, Frank Harris, Lou Ann Brown, Satheesh Chonat, Nitya Bakshi, Chris A. Rees, Carlton Dampier, Claudia R. Morris   +10 more
wiley   +1 more source

The Influence of the Installation Angle of a Blade’s Low-Pressure Edge on the Cavitation Performance of Francis Pump-Turbines

Fluids
The low-pressure edge of a pump-turbine runner blade is more prone to cavitation than other parts. The installation angle of the blade’s low-pressure edge is one of the key parameters affecting the cavitation performance of the pump-turbine. Based on the
Hui Ruan, Wenxiong Chao, Xiangyang Li, Qingyang Zhang, Lvjun Qing, Chunmei Wei   +5 more
doaj   +1 more source

Studies of a combined way of flame stability in ramjet combustor

Defence Technology, 2018
numerical simulation was conducted to study the influence of bleeding. The Euler-Lagrange method was used to investigate the two-phase turbulent combustion flow.
Jia-xin Tao
doaj   +1 more source