Results 81 to 90 of about 2,535,910 (353)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Prediction of shut-off head for centrifugal pumps based on grey theory and GA-BP neural network
AIP AdvancesCalculating the shut-off head for centrifugal pumps poses significant challenges due to inaccuracies in existing empirical methods. This paper presents a predictive model based on extensive experimental data, employing a back propagation (BP) neural ...
Dehui Yu +6 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Proton pump inhibitors alter the composition of the gut microbiota
Gut, 2015 Objective Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux.
M. Jackson +11 more
semanticscholar +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Frontiers in Microbiology, 2018 The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage.
Josselin Bodilis +6 more
doaj +1 more source
HEAT PUMP AND AIR CONDITIONING GRADING SYSTEMS AND METHODS [PDF]
, 2019 An expectation module determines an expected average power consumption of a heat pump for a predetermined period as a function of indoor and outdoor temperatures of the building during the predetermined period.
Alsaleem, Fadi Mohammad
core +1 more source
Phytoplankton as Key Mediators of the Biological Carbon Pump: Their Responses to a Changing Climate
, 2018 The world’s oceans are a major sink for atmospheric carbon dioxide (CO2). The biological carbon pump plays a vital role in the net transfer of CO2 from the atmosphere to the oceans and then to the sediments, subsequently maintaining atmospheric CO2 at ...
Samarpita Basu, K. Mackey
semanticscholar +1 more source
An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
eLife, 2017 Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope.
Zhao Wang +8 more
semanticscholar +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source