Results 61 to 70 of about 44,804 (276)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Lumbar Puncture

Acute Medicine Journal, 2011
Most junior doctors learn common practical procedures, like lumbar puncture, on the job. This usually involves unstructured observation, demonstration and then supervised practice. Thus, most doctors have learned to perform a lumbar puncture without studying the theory of the procedure in any detail.
openaire   +3 more sources

An Out‐of‐Place Etiology: Recognizing FMR1 Premutation in the Memory Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The FMR1 gene premutation (55–200 CGG repeats) is usually associated with a wide range of symptoms and phenotypes within the Fragile X‐tremor/ataxia syndrome (FXTAS), but may also manifest as predominant or isolated cognitive decline. We describe three male patients referred for progressive cognitive impairment and behavioral changes. Standard
Guido Greco, Caterina Motta, Enrica Marchionni, Maria Rosaria D'Apice, Carlangelo Carrese, Giuseppe Novelli, Alessandro Martorana, Chiara Giuseppina Bonomi   +7 more
wiley   +1 more source

Adaptive Segmented Aggregation and Rate Assignment Techniques for Flexible-Length Polar Codes

Entropy
Polar codes have garnered a lot of attention from the scientific community, owing to their low-complexity implementation and provable capacity achieving capability.
Souradip Saha, Shubham Mahajan, Marc Adrat, Wolfgang Gerstacker   +3 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Endoscopic-assisted descending aortic replacement through a small intercostal incision: a case report

Journal of Cardiothoracic Surgery, 2022
Background Descending aortic replacement often involves making large incisions; thus, it results in massive invasions. We report the case of a patient with dilated descending aorta treated using endoscopic-assisted descending aortic replacement with ...
Takeshi Wada, Hidenori Sako, Kenya Kizu, Takahiro Tashima, Tetsushi Takayama, Shinji Miyamoto   +5 more
doaj   +1 more source

Embedding punctured manifolds [PDF]

Proceedings of the American Mathematical Society, 1965
THEOREM. Let M-x be embedded differentially in a differential manifold N of dimension n, in such a way that the normal bundle of the embedding is fibre homotopically trivial. Then there is a map of degree one onto the smash product N-->Sn-m A M. (The degree should be taken mod 2 if M or N is not orientable, and with respect to the compact cohomology of
openaire   +2 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Optimized puncturing distributions for irregular non-binary LDPC codes

, 2010
In this paper we design non-uniform bit-wise puncturing distributions for irregular non-binary LDPC (NB-LDPC) codes. The puncturing distributions are optimized by minimizing the decoding threshold of the punctured LDPC code, the threshold being computed ...
Declercq, David, Gorgoglione, Matteo, Savin, Valentin   +2 more
core   +1 more source