Results 191 to 200 of about 100,917 (264)

Pupil size predicts exploration through critical slowing in prefrontal dynamics. [PDF]

Commun Biol
Shourkeshti A, Abbaszadeh M, Marrocco G, Jurewicz K, Moore T, Ebitz RB.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Research progress on postoperative higher-order aberrations after ICL implantation: patterns of change, influencing factors, and associated visual disturbances. [PDF]

Front Med (Lausanne)
Hao Z, Zhao L, Pei Y, Nie L.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner. [PDF]

Biomed Opt Express
Kunala K, Xia Y, Ayubi GA, Kowalski B, Desai AX, Lippman D, Bentley J, Dubra A.   +7 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Increased Baseline Pupil Size Linked to Uncertainty Avoidance in Decision Making. [PDF]

Eur J Neurosci
Kakaei E, Schlecht A, Hauser TU.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Predictive Accuracy of Glasgow Coma Scale and Pupillary Data on Presence of Traumatic Brain Injury. [PDF]

J Clin Med
Schüller D, Wafaisade A, Lefering R, Migliorini F, Bolierakis E, Weuster M, Kubo Y, Fröhlich M, Driessen A, TraumaRegister DGU.   +9 more
europepmc   +1 more source

The impact of the pupil size artifact on pupil-based eye-tracking data in reading tasks: Assessment and compensation. [PDF]

Behav Res Methods
Culemann W, Heine A, Hooge ITC.
europepmc   +1 more source