Results 191 to 200 of about 15,986,900 (239)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements. [PDF]

J Neurosci
Zimmer-Harwood P, Picard S, King AJ, Dahmen JC.   +3 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

One-Year Effects of the FIT FIRST 20 High-Intensity and Multisport Physical Education Program on Physical Fitness and Psychological Outcomes in Early Adolescents: A Cluster-Randomized Controlled Trial. [PDF]

Scand J Med Sci Sports
Cimenti C, Thøgersen-Ntoumani C, Larsen MN, Tarantino G, Koch S, Eckert C, Meiner CB, Prisak C, Krustrup P, Ntoumanis N.   +9 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner. [PDF]

Biomed Opt Express
Kunala K, Xia Y, Ayubi GA, Kowalski B, Desai AX, Lippman D, Bentley J, Dubra A.   +7 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Estradiol and non-REM sleep attenuate physiological and emotional responses to social-evaluative stress in healthy women. [PDF]

BMC Med
Meth EMS, Nôga DA, Wedzinga F, Almajni A, Pacheco AP, Rossi V, Simonsson PC, Heel C, Zetterlund C, Noory SFM, Danek M, Xue P, Benedict C.   +12 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype. [PDF]

Sleep
van der Zwet G, Bor Z, Bos R, van Dorp R, Pape LM, van der Zwet LCA, van Dijk EHC, van de Stadt H, McGlashan EM, Michel S, Kervezee L.   +10 more
europepmc   +1 more source