Results 61 to 70 of about 15,986,900 (239)

A CHILD AND MERE HIRELING IN THE URBAN SOCIETY OF THE HETMANSHYNA IN THE EIGHTEENTH CENTURY

Місто: історія, культура, суспільство, 2018
The article examines the use of hired child labour in the Hetman State society with an emphasis on its peculiarities inherent to the urban population.
Ihor Serdiuk
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

pupil: Pupil Player and Pupil Capture release v0.5.4

, 2015
<p>This is a quick update following release of version 0.5.</p> <p>MJPEG recording is now officially implemented and supported on Mac and Linux both in bundle and running from source.
Andrew Xia, mkassner, Michael Barz, Will, Ignacio, Rafael Picanço, Toshi Kurauchi   +6 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Implications of Retrograde Behaviours on Visual and Cycling Behaviour of Normal Cyclists

Promet (Zagreb)
In China and other developing countries, some bicycle riders exhibit retrograde behaviour, which affects the riding safety of normal cyclists. The effect of retrograde behaviour on visual search and cycling behaviours of normal cyclists is investigated ...
Baojie WANG, Wei YANG, Ziyao LIU, Guohua LIANG   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The indicators of pupil opinion and teacher interactivity for inquiry-based science teaching [PDF]

, 2010
In order to establish those practices which underpin a science teaching performance that combines pupil enthusiasm and creative classrooms, it will be necessary to uncover evidence of inquiry-based learning experiences in science that can provide a ...
Mcnally, James, Smith, Colin, Blake, Allan   +2 more
core   +3 more sources

Environmental Awareness Through Project-Based Learning in Primary Social Science Classrooms in Dhaka: A Qualitative Analysis

Inovacije u Nastavi
The impact of project-based learning on enhancing environmental consciousness among elementary school pupils in a Dhaka school and encouraging a culture of lifelong learning among teachers is investigated in the present study.
Khondokar Sabera Hamid
doaj   +1 more source