Results 71 to 80 of about 15,986,900 (239)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Pupil Cycle Time in optic neuritis
, 2014 Pupil Cycle Time (PCT), induced by a slit-lamp, has previously been used to quantify optic nerve conduction time in patients with optic neuritis (ON). We tested a new way of inducing PCT by adjusting the intensity of a standard computer screen according ...
Cedric Lamirel; Tristan Himpens; Antoine Moulignier; Catherine Vignal; Laurence Salomon; Isabelle Cochereau; Jean Lorenceau
core
Pupil diameter in migraine and tension headache [PDF]
, 1987 Pupil diameter was measured in darkness and in dull and bright illumination in 39 migrainous patients and in 15 tension headache sufferers during headache. In 21 migrainous patients, measurements were repeated during the headache-free interval.
Drummond, P.D.
core
Research on Warning Colors Optimization for Safety Enhancement of Achilles Tendon Protective Shoes
Pige Kexue Yu GongchengObjectiveAchilles tendon protective shoes are medical orthoses that must be worn after Achilles tendon rupture surgery. Currently, these shoes predominantly feature black and gray color schemes and lack conspicuous warning markings, making them visually ...
Dandan XUE
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Urban MobilityIn South Korea, railway stations provide an important setting for examining information accessibility because travelers must search for and interpret dynamically updated information while moving.
Jihye Baek +3 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Monitoring Cognitive and Emotional Processes Through Pupil and Cardiac Response During Dynamic Versus Logical Task [PDF]
, 2010 The paper deals with the links between physiological measurements and cognitive and emotional functioning. As long as the operator is a key agent in charge of complex systems, the definition of metrics able to predict his performance is a great challenge.
Pastor, Josette +3 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source