Results 131 to 140 of about 28,333 (258)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Comprehensive Review of Nystagmus and Vertigo Diagnostics: From Pathological Foundations to AI-Driven Telemedicine. [PDF]

Sensors (Basel)
Balasubramanian K, Danesh A, Pandya A.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Evaluation of static and dynamic pupil responses in patients with acromegaly with automatic pupillometer. [PDF]

BMC Ophthalmol
Erdem S, Dursun ME, Ava S, Karahan M, Hazar L, Sevuk DC, Pekkolay Z, Keklikci U.   +7 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pupillary responses to the glare illusion in normal pressure hydrocephalus: insights into network dysfunction and neurodegenerative comorbidities. [PDF]

Neurol Sci
Kawamura A, Kinzuka Y, Kawakami N, Morihara K, Kakinuma K, Katsuse K, Matsubara S, Iseki C, Kanno S, Nakauchi S, Suzuki K.   +10 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Visual acuity in controls and patients measured with Maxwellian view and a 3 mm pupil: Examining potential effects of inherent and induced aberrations. [PDF]

PLoS One
Parimi V, Elsner AE, Clark CA, King BJ.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Advances in ocular motor and pupil biomarkers for neurological disorders. [PDF]

Brain Commun
Coito A, Brügger D, Brémovà-Ertl T, Massatsch P, Abegg M, Weber KP, Salmen A.   +6 more
europepmc   +1 more source