Results 201 to 210 of about 799,066 (314)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Daily Mile and children's physical activity, mental health and educational performance: a quasi-experimental study in Greater London primary schools. [PDF]

BMJ Open Sport Exerc Med
Ram B, Cunningham M, Falaschetti E, Chalkley A, Woodcock T, van Sluijs E, Hargreaves D, Saxena S.   +7 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The distribution of school-aged adolescents' free sugar intake across the day: A cross-sectional study. [PDF]

Eur J Clin Nutr
Murphy M, Hewitt T, Stewart A, Morrison B, Duff R, Sitch A, Hurley K, Griffin T, Adamson A, Spence S, Rowland M, Adab P, Pallan M.   +12 more
europepmc   +1 more source

THE TONIC PUPIL [PDF]

British Journal of Ophthalmology, 1942
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

'Science Fun Days': Opportunities for Connecting Primary School Pupils With Nature and Microbiology. [PDF]

Microb Biotechnol
Archer EJ, Whitby CB, Ferguson RMW, Clark DR, Skinner BM, Henderson DK, Solanke OS, Sturrock AM, Boreham R, McGenity TJ.   +9 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Assessing what matters: integrating social-emotional learning into classroom assessment for pupil well-being in Ghanaian basic schools. [PDF]

Sci Rep
Ntumi S, Courage Kwaku K, Agyemang K, Nyarko B.   +3 more
europepmc   +1 more source

THE TABETIC PUPIL [PDF]

British Journal of Ophthalmology, 1941
openaire   +4 more sources