Results 221 to 230 of about 245,314 (313)

Emergency burr-hole evacuation for subacute SDH with uncal herniation: a case report of near-complete neurological recovery despite bilateral occipital infarction. [PDF]

Int J Surg Case Rep
Naghizadeh S, Zohrabi-Fard M, Tavanaei R, Mirzaei S, Avvalabadi P, Oraee-Yazdani S.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Adolescent perspectives on the barriers and facilitators of engagement in healthy lifestyle behaviours: a focus group study from the European SEEDS project. [PDF]

BMJ Open
Wargers A, Senequier A, Elphick CM, Mölenberg FJM, Williams CA, Llauradó E, Solà R, Manios Y, Mavrogianni C, Murray C, Jansen W, Vlachopoulos D.   +11 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hospital admissions among adolescents with local authority care experience or special educational needs in England: a population-based cohort study using linked administrative data from health, education and social care services. [PDF]

BMJ Public Health
Blackburn RM, Kokosi T, Heys M, Gilbert R, Zylbersztejn A.   +4 more
europepmc   +1 more source

Abnormalities of Pupils.

Internal Medicine, 1996
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Listening comprehension and its influence on reading fluency in primary students with special educational needs: a study in mainstream inclusive classrooms. [PDF]

Front Psychol
Zhang S, Ren D, Wu J.
europepmc   +1 more source