Results 41 to 50 of about 6,030 (191)

Lead intoxication in a puppy - a case report

open access: yesVeterinární Medicína, 2002
Lead intoxication in a puppy is described. The puppy was submitted to surgical procedure for suspicion of acute abdominal pain. Diagnosis was established on the basis of the presence of eroded lead weights in stomach, biochemical and hematological blood ...
E. Srebočan   +5 more
doaj   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

open access: yesAdvanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin   +2 more
wiley   +1 more source

Molecular Prevalence and Risk Factors of Campylobacter Infection in Puppies in the Nairobi Metropolitan Region, Kenya

open access: yesVeterinary Medicine International, 2023
Campylobacter species are widely distributed pathogens; however, data on its epidemiology in puppies remain scanty, especially in Kenya. A cross-sectional study was conducted in the Nairobi Metropolitan Region to determine molecular prevalence and ...
Sharon N. Mbindyo   +7 more
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

Genetic characterization and predominance of the new CPV-2a variant in clinical cases of canine parvovirus in the western region of Rio Grande do Sul, Brazil [PDF]

open access: yesCiência Rural
: Canine parvovirus 2 (CPV-2) is an important causative agent of segmental enteritis in young dogs and has globally distributed variants and subtypes.
Bianca de Castro Leal   +6 more
doaj   +1 more source

Suspected clinical toxoplasmosis in a 12-week-old puppy in Singapore

open access: yesBMC Veterinary Research, 2023
Background Toxoplasma gondii is traditionally known as a parasite of felids, with possible infection in intermediate hosts such as dogs and humans, and thus a disease of public health significance.
Audrey Chen   +8 more
doaj   +1 more source

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

open access: yesAdvanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang   +11 more
wiley   +1 more source

How to Fight Puppy Mills: Toughening the Sentences for Animal Abuse in the Post-Communist Region

open access: yesAnimals, 2020
This study seeks answers to questions regarding the kind of main legislative issues and obstacles there are in providing a legal solution to the problem of illegal puppy mills in the post-communist context, how criminal law experts opine about toughening
Lukáš Novotný
doaj   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

open access: yesAdvanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao   +13 more
wiley   +1 more source

Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study

open access: yesScientific Reports
Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis on very small hearts.
Olga Szaluś-Jordanow   +13 more
doaj   +1 more source

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