Results 51 to 60 of about 6,236 (222)

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study

Scientific Reports
Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis on very small hearts.
Olga Szaluś-Jordanow, Karolina Barszcz, Wojciech Mądry, Michał Buczyński, Michał Czopowicz, Adam Gierulski, Agata Moroz-Fik, Zofia Nowek, Marcin Mickiewicz, Michał Grzegorczyk, Jakub Jaroszewicz, Sylwia Tarka, Tomasz Stępień, Wojciech Święszkowski   +13 more
doaj   +1 more source

Thoracic ectopia cordis, sternal agenesis, partial ectopia hepatica and fissure abdominalis in a German Shepherd puppy with milder incomplete pentalogy of Cantrell. Clinical case

Revista Científica
A newborn German Shepherd breed male puppy was presented with the complaint that some organs were formed outside the chest and abdomen. The rhythmic movements of the swelling under the chest pointed out the heart and the swelling under the abdomen was ...
Emsal Sinem Ozdemir–Salci, Koray Yildirim   +1 more
doaj   +1 more source

Genetic characterization and predominance of the new CPV-2a variant in clinical cases of canine parvovirus in the western region of Rio Grande do Sul, Brazil [PDF]

Ciência Rural
: Canine parvovirus 2 (CPV-2) is an important causative agent of segmental enteritis in young dogs and has globally distributed variants and subtypes.
Bianca de Castro Leal, José Conrado dos Santos Jardim, Maria Elisa Trost, Bruno Leite dos Anjos, Paula Fonseca Finger, Carolina Kist Traesel, Mário Celso Sperotto Brum   +6 more
doaj   +1 more source

Suspected clinical toxoplasmosis in a 12-week-old puppy in Singapore

BMC Veterinary Research, 2023
Background Toxoplasma gondii is traditionally known as a parasite of felids, with possible infection in intermediate hosts such as dogs and humans, and thus a disease of public health significance.
Audrey Chen, Max Boulay, Stacy Chong, Kelvin Ho, Amy Chan, Jasmine Ong, Charlene Judith Fernandez, Siow Foong Chang, Him Hoo Yap   +8 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

How to Fight Puppy Mills: Toughening the Sentences for Animal Abuse in the Post-Communist Region

Animals, 2020
This study seeks answers to questions regarding the kind of main legislative issues and obstacles there are in providing a legal solution to the problem of illegal puppy mills in the post-communist context, how criminal law experts opine about toughening
Lukáš Novotný
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies

Frontiers in Nutrition
Time around parturition is a stressful period for both bitches and their puppies. The use of probiotics has been proposed, e.g., in pigs, to improve health status of sows, their reproductive performances and in turn, the health and performance of their ...
Quentin Garrigues, Amélie Mugnier, Sylvie Chastant, Flavie Sicard, Flavie Sicard, Jean-Charles Martin, Ljubica Svilar, Ljubica Svilar, Mathieu Castex, Manuel Guillermo Ramis-Vidal, Manuel Guillermo Ramis-Vidal, Nicoletta Rovere, Laurine Michaud, Pauline David, Elodie Mansalier, Ana Rodiles, Hanna Mila, Emmanuelle Apper   +17 more
doaj   +1 more source