Results 71 to 80 of about 906,409 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Impact of social cultural factors on Purchase intention of counterfeit mobile phones

open access: yes, 2022
: Counterfeit consumption has been on an upsurge globally aided by comparative higher trade margins and increasing demand for renowned brands at lower prices. Social cultural factors have been found to play a major role in the growth of the trade as they
B.M. Muia, C. Lagat, R. Bonuke
core   +1 more source

Determinants of Consumer’s Purchase Intention on Fresh E-Commerce Platform: Perspective of UTAUT Model

open access: yesSAGE Open, 2021
Despite the booming market of fresh food, the fresh e-commerce platform holds only a limited market share, owing to the lack of habitual usage of these platforms.
Lingming Chen   +5 more
doaj   +1 more source

Purchase Intention Through Social Media Commerce with Age and Gender as Moderating Variables: An Empirical Study

open access: yesMajalah Ilmiah Bijak, 2023
Purchase intention helps entrepreneurs to decide where the geographic market is and how to segment the customers where the products and services are sold on social commerce media.
Nabilla Paramitha   +1 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Research on the Purchase Behavior of Owner–Pet Matching Outfits Based on the Extended Theory of Planned Behavior

open access: yesBehavioral Sciences
With the rapid expansion of the pet economy, owner–pet matching outfits have grown increasingly popular among pet owners. Grounded in the extended theory of planned behavior, this study investigates the key determinants of pet owners’ purchase intentions
Sisi Chen, Diqing Qian, Zengrui Xiao
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Exploring the impact of mobile marketing tools on the purchase intention of iberian consumers [PDF]

open access: yes
Mobile devices have become an integral part of our daily lives, and people use them for numerous activities, including shopping. As a result, businesses must utilize mobile marketing tools to communicate with their customers and offer personalized and ...
Teixeira, Sara, Nunes, Ana
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Website Quality: The Effect with Perceived Flow and Purchase Intention in Travel Customers in Malang City [PDF]

open access: yes, 2020
To gain consumer buying interest, can not be separated from the presentation of a quality website, website quality is an important factor in e-commerce if you want to evaluate the performance of e-commerce itself, website quality not only affects ...
Prasetya, Dwi Arman   +4 more
core  

Home - About - Disclaimer - Privacy