Results 81 to 90 of about 57,844 (315)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Exploring purchase intention in metaverse retailing: Insights from an automotive platform

As an integration of cutting-edge digital technologies, the metaverse is set to revolutionize online retailing. This study employed a well-established metaverse automotive retailing platform in China to explore the paths influencing consumers' purchase ...
Behl, Abhishek, Lv, Yang, Urbonavičius, Sigitas,, Zhang, Justin Zuopeng, Urbonavicius, Sigitas, Zhang, Haowei,, Hollebeek, Linda Desiree,, Lv, Yang,, Zuopeng Zhang, Justin, Hollebeek, Linda,, Zhang, Haowei, Hollebeek, Linda D., Hollebeek, Linda, Behl, Abhishek,, Lund University., Zhang, Justin Zuopeng,, Zuopeng Zhang, Justin,   +16 more
core   +1 more source

Influence of website attributes on consumer’s online purchase intention in Malaysia

, 2022
Due to the global pandemic of COVID-19, the world has faced the difficulties in conducting business activities. The COVID-19 pandemic has interrupted shopping activities in Malaysia as consumers are steadily switching from offline to online purchases ...
Hussin, Siti Rahayu, Adedoja, Omoloju Mariam, Wong, Foong Yee   +2 more
core   +1 more source

Brand Awareness, Social Media Marketing, and Purchase Intent: Does Credibility Mediate the Impact?

Indonesian Interdisciplinary Journal of Sharia Economics
This study investigates the impact of social media marketing and brand awareness on purchase intention with influencer credibility as a mediating variable. Quantitative methodologies were implemented during the investigation.
Larasati Larasati, Wiyadi Wiyadi, Rini Kuswati, Edy Purwo Saputro   +3 more
doaj   +1 more source

Influences of background factors on consumers’ purchase intention in China’s organic food market: Assessing moderating role of word-of-mouth (WOM)

Cogent Business & Management, 2021
The present study aims to clarify how background factors influence consumers’ intention of purchasing organic food from individual, social, and information perspectives (i.e., health consciousness, self-perceived vegetarian, as well as labeling). Another
Shimiao Li, Nor Siah Jaharuddin
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An extended model of the theory of planned behaviour to predict purchase intention for local brand vehicles produced in Malaysia

, 2023
The single-digit growth rate of the Malaysian Automotive sector has experienced a slight decline elicited by Covid-19 and a change in consumers product evaluation criteria.
Ho, Jo Ann, Chinedu, Anyanwu Hilary, Haron, Sharifah Azizah, Hashim, Ahmad Hariza   +3 more
core   +1 more source

The Effect of Consumer Ethnocentrism, Brand Image, and Perceived Quality,on Purchase Decisions With Purchase Intention as Intervening Variable

Jurnal Akuntansi, Manajemen dan Ekonomi, 2018
The purpose of this research is to know and analyze the effect of consumer ethnocentrism, brand image, and perceivedquality of Eiger outdoor equipment product to consumer purchase decision, and to test purchase intention as intervening variable between ...
Dziqry Muhammad Haikal
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Managing price changes: Role of consumer thinking styles on perceived price fairness and purchase intention [PDF]

, 2022
Consumers expect companies to practice fair pricing. Understanding the underlying cognitive mechanism that determines consumers' price fairness perceptions is significant.
Shaw, Sayanti, Bejtkovský, Jiří, Chovancová, Miloslava   +2 more
core