Results 51 to 60 of about 279,471 (314)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Perceptions, values and behaviour: The case of organic foods [PDF]

open access: yes, 2005
This analysis of the Danish organic food market investigates the relationships between household purchasing behaviour and stated values, motives and concerns. Attention is also given to the importance of sales chan-nels and the functions of labelling. We
Andersen, Laura Mørch   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

An evaluation of socio-economic classification systems : a thesis presented in partial fulfilment of the requirements for the degree of Master of Business Studies at Massey University [PDF]

open access: yes, 1985
This thesis evaluates some commonly used socio-economic classification systems. Some of the systems evaluated have been used for many years in the market research industry in New Zealand whilst others are recent additions or are more commonly used in ...
Mayo, Robert William
core  

Children’s Food and Drink Purchasing Behaviour ‘‘Beyond the School Gate’’ : The Development of a Survey Module [PDF]

open access: yes, 2013
Copyright © 2013 Wendy J.Wills et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bromley, C.   +5 more
core   +4 more sources

Purchase Behaviours of Generation Y

open access: yesAnnales Universitatis Mariae Curie-Skłodowska, sectio H – Oeconomia, 2020
<p>The purpose of this article is to verify the hypothesis related to the possibility to meet the needs of young consumers who are both capricious and unreliable in their purchase choices. This article concerns the values by which Generation Y are driven, as well as their life purposes, consumption-related behaviours, factors that have an impact ...
openaire   +2 more sources

The effect of service convenience on post‐purchasing behaviours [PDF]

open access: yesIndustrial Management & Data Systems, 2010
Purpose – This paper attempts to investigate the casual relationships among service convenience, perceived service value, perceived service guarantee strength, customer satisfaction, and loyalty. Although previous studies have addressed the importance of these variables, the understanding of the mediating effect of customer‐perceived service value and ...
Chang K.-C.   +3 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Herding behaviour in mutual fund industry, evidence from Tehran Stock Exchange [PDF]

open access: yesمطالعات تجربی حسابداری مالی, 2015
Behavioural finance approach gives us the possibility that in addition to the traditional concept of finance, human behaviour and psychological factors also result in variances in stock prices.
Jafar Babajani   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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