Results 51 to 60 of about 5,258,153 (278)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Business Analytics in Strategic Purchasing: Identifying and Evaluating Similarities in Supplier Documents

Applied Artificial Intelligence, 2021
The increasing digitalization in the automotive industry is influencing the structure of the traditional value chain and calls for the handling of large amounts of data to remain competitive in a constantly changing environment.
Frank Bodendorf, Benedict Wytopil, Jörg Franke   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Guidance on how to balance the purchasing environment and processes to save resources - a validity examination of a holistic model

Cogent Business & Management
Despite the evolution of purchasing operations over many years, a comprehensive perspective is lacking in practice, leading to inefficiencies. This study aims to validate a model designed to guide how to balance the purchasing environment.
Maria M. Wittinger, Krisztina Demeter
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Development of a Purchasing and Supply Management Maturity Framework [PDF]

Operations and Supply Chain Management: An International Journal, 2015
The goal of this contribution is to present a Purchasing and Supply Management Maturity Framework based on the findings of a comprehensive literature and empirical research and a comparative analysis of maturity models published between 1983 and 2014 as well as (management) frameworks published between 1998 and 2014 in Purchasing and Supply Management (
openaire   +3 more sources

THE ROLE OF THE E-PROCUREMENT IN THE PURCHASING PROCESS [PDF]

Annals of the University of Oradea: Economic Science, 2011
This article aims to examine the role of the E-procurement forms in the six phases of the purchasing process. The paper starts with an introductory part about the purchasing process.
Pop Sitar Corina
doaj  

Theoretical framework for knowledge sharing and co-creation of messages on digital platforms: a consumer knowledge management perspective

Consumer Behavior Review, 2022
Purpose: The main objective of this study was to develop and propose a comprehensive conceptual theoretical framework on the relationship between digital platforms, UGC, message co-creation, knowledge sharing, consumer decision-making and purchasing ...
Rachel Barker, Janette Hanekom
doaj   +1 more source

Explainable Next-Purchase Recommendations: A Multistakeholder Framework

We present a next-purchase recommendation system that combines advanced algorithms with explainable AI (XAI) to learn individual customer preferences from purchase histories and deliver personalized recommendations that enhance user engagement and inform marketing strategy.
Mozolewski, Maciej, Zych, Honorata, Manai, Sabri, Kutt, Krzysztof, Nalepa, Grzegorz J.   +4 more
openaire   +3 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source