Results 61 to 70 of about 46,457 (296)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Purchasing process models: Inspiration for teaching purchasing and supply management [PDF]

, 2019
Most scholars of purchasing and supply management (PSM) are familiar with some form of a purchasing process model (PPM). A PPM is the visual representation of the sequence of activities that constitute purchasing and supply management.
Raaij, E.M. (Erik) van, van Raaij, Erik, Bäckstrand, Jenny,, Chen, Clive,, Suurmond, Robert,, Chen, Clive, Backstrand, Jenny, Suurmond, Robert; id_orcid, Suurmond, R. (Robert), Chen, C. (Chongshuang), van Raaij, Erik M.,, Bäckstrand, J. (Jenny), Chen, C. (Clive), Bäckstrand, J., Suurmond, Robert   +14 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Purchasing Power Parity Hypothesis in Developing Economies: Some Empirical Evidence from Sri Lanka [PDF]

The purchasing power parity (PPP) hypothesis has attracted a lot of attention from academics and policy-makers particularly, during the recent float. Most previous studies used data from the developed world.
Guneratne B Wickremasinghe
core   +2 more sources

Pairwise tests of purchasing power parity

, 2009
Given nominal exchange rates and price data on N + 1 countries indexed by i = 0,1,2,…, N, the standard procedure for testing purchasing power parity (PPP) is to apply unit root or stationarity tests to N real exchange rates all measured relative to a ...
Yamagata, T., Lyudmyla Hvozdyk, Smith, Ron P., Smith, Ron P, Hvozdyk, Lyudmyla, M. Hashem Pesaran, Ron P. Smith, Pesaran, M.H., Hvozdyk, L., Yamagata, Takashi, Takashi Yamagata, Pesaran, M Hashem   +11 more
core   +1 more source

Nonlinear trend stationarity of real exchange rates: the case of the Mediterranean countries [PDF]

, 2008
The aim of this article is to provide additional evidence on the fulfilment of the Purchasing Power Parity hypothesis in the so-called Mediterranean countries.
Ordóñez, Javier, Cuestas, JC, Ordóñez, J, Cuestas, Juan Carlos, Camarero, M, Camarero, Mariam   +5 more
core   +1 more source

Assessment of Strategic Healthcare Purchasing Arrangements and Functions Towards Universal Coverage in Tanzania [PDF]

International Journal of Health Policy and Management, 1999
Background  Strategic health purchasing in low- and middle-income countries has received substantial attention as countries aim to achieve universal health coverage (UHC), by ensuring equitable access to quality health services without the risk of ...
August Kuwawenaruwa, Suzan Makawia, Peter Binyaruka, Fatuma Manzi   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Colombian Purchasing Power Parity Analysed Using a Framework of Multivariate Cointegration [PDF]

This paper tests for purchasing power parity (PPP)between Colombia and its main trading partners using the Johansen framework of multivariate cointegration.
Peter Rowland, Hugo OLiveros C.
core