Results 81 to 90 of about 5,258,153 (278)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Examining the role of production and purchasing supply chain management using PLS-SEM approach in the UK textile industry [PDF]

open access: yesMATEC Web of Conferences
This study focuses on the specific types of supply chain strategies throughout the UK textile industry as extant literature has either emphasized on the fashion apparel industry or on sub-industry of fast fashion. Likewise, this study is quite beneficial
Komal Samina, Saad Sameh M
doaj   +1 more source

Negotiation for Purchasing Professionals

open access: yes, 2013
Negotiation for Purchasing Professionals provides purchasers and their team with the tools and tactics needed for a detailed, planned approach to negotiation.
O'Brien, Jonathan
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Data-Driven Analysis of Omnichannel Purchasing Pathways: Age and Gender Effects Across Retail Product Categories

open access: yesProduction Engineering Archives
The emergence of omnichannel environments has transformed consumer purchasing into a highly complex, multistage decision-making process, generating nonlinear demand signals that heavily influence retail logistics, inventory optimization, and production ...
Madudová Emília   +2 more
doaj   +1 more source

Collaborative electronic purchasing within an SME consortium [PDF]

open access: yes, 2008
The main function of purchasing is to assure the supply with required goods and services. Large organisations have both finances and knowledge to implement optimised purchasing resources, typically using information and communications technology (ICT) to
Vogt, Oliver
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Purchasing power parity in G-7 countries: Further evidence based on ADL test for threshold cointegration [PDF]

open access: yes
This study applies a newly-developed Autoregressive Distributed Lag (ADL) test for threshold cointegration, proposed by Li and Lee (2010) to test the validity of long-run purchasing power parity (PPP) for G-7 countries over the January 1994 to April 2010.
Pei-I Chou, Chia-hao Lee, Tsangyao Chang
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Understanding Socioeconomic Challenges of Environmental Sustainability through Consumer Awareness, Buying Behaviour and Green Marketing [PDF]

open access: yesSocioEconomic Challenges
Socioeconomic challenges to environmental sustainability are closely linked to consumer awareness and green buying behavior. The aim of this review paper is to identify the key factors influencing consumer awareness and green buying behavior among Nepali
Dhavindra Rawal, Padam Raj Joshi
doaj   +1 more source

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