Results 71 to 80 of about 22,212 (305)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Determinants of Intention to Purchase Online Airline Ticket

تحقیقات بازار یابی نوین, 2014
Nowadays development of information technology has caused online shopping continues to gain more acceptance by travelers that make airlines be care about factors affecting online ticket purchasing.
alireza Hadadian, Amirhossein Bagherieh
doaj  

Product Quality and Packaging: Enhancing Purchase Decisions through Purchase Intention as a Mediating Variable (Study on SilverQueen Products for Gen Z in Malang City)

Journal of Economics Education and Entrepreneurship
The purpose of this study was to analyze and test the effect of product quality and product packaging on purchasing decisions with purchase intention as a mediating variable on SilverQueen products for Gen Z in Malang City.
Aliqul Khoiril Umam, Nur Laili Fikriah
doaj   +1 more source

ANTESEDEN DARI PURCHASE INTENTION

Jurnal Ekonomi Trisakti, 2023
Tujuan penelitian ini adalah untuk memahami bagaimana hubungan financial value, functional value, individual value, social value, dan customer engagement dengan niat meningkatan purchase intention Zara di Jakarta. Informasi yang digunakan dalam studi kasus ini adalah Zara apparel consumers.
M. Restu Mulyana, null Ina Oktaviana Matusin   +1 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Customers’ Perceptions and Purchasing Behavior at Uacon Fisherfolks Fishermen Cooperative Souvenir Shop

Journal of Arts, Humanities and Social Science
Souvenir shops play an important role in promoting local culture, supporting community livelihoods, and enhancing tourism experiences. This study examined the relationship between customers’ perceptions and purchasing behavior at the Uacon Fisherfolks ...
Khate Nathalie Mirador, John Mark Astorga, Jhillian Mhae Mirador, Aprilyn Hebron, Juralyn Babtisma, Shania Kate Ebidag, Joyce Reboso, Allen Ramirez, Jerico De Guzman   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

BRAND IMAGE AS A MEDIATION OF ELECTRONIC WORD OF MOUTH ON PURCHASING INTENTION OF LANEIGE

, 2020
The purpose of the study was to know and analyze the role of brand image as a mediator of the impact of the Electronic Word of Mouth on purchasing intention of Laneige’s product. A sample of 100 respondents used a purposive sampling technique.
Supradita, Chikita Fatimasokasari, Laksana, Dwi Hari, Darpito, Surpiko Hapsoro   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Customers' pereceptions of corporate social responsibility and their purchasing intention - A study in the home appliance sector

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kinh tế và Quản trị kinh doanh, 2020
This study is to investigate customers’ perceptions of 4 types of responsibilities in Carroll’s CSR pyramid (1991), including economic, legal, ethical and philanthropic responsibilities; and the effects of their perceptions of CSR on purchasing intention.
Nguyễn Phan Thanh Nhã, Lê Thị Thanh Xuân   +1 more
doaj