Results 31 to 40 of about 25,785 (225)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
RD-flatness and RD-injectivity
, 2006 It is proved that every commutative ring whose RD-injective modules are $\Sigma$-RD-injective is the product of a pure semi-simple ring and a finite ring.
François Couchot, Fuchs L., Renault G.
core +4 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
On the grade of modules over Noetherian rings
, 2007 Let $\Lambda$ be a left and right noetherian ring and $\mod \Lambda$ the category of finitely generated left $\Lambda$-modules. In this paper we show the following results: (1) For a positive integer $k$, the condition that the subcategory of $\mod ...
Huang, Zhaoyong
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Modules with irrational slope over tubular algebras
, 2014 Let $A$ be a tubular algebra and let $r$ be a positive irrational. Let ${\mathcal D}_r$ be the definable subcategory of $A$-modules of slope $r$. Then the width of the lattice of pp formulas for ${\mathcal D}_r$ is $\infty$.
Harland, Richard, Prest, Mike
core +1 more source
Indecomposable Decompositions of Finitely Presented Pure-Injective Modules
Journal of Algebra, 1997 This is a well-written paper which presents interesting criteria for a finitely presented pure-injective module to have a decomposition into indecomposable summands. A module \(M\) is called pure-injective (or algebraically compact) if it has the injectivity property with respect to all pure exact sequences, and \(M\) is called completely pure ...
Gómez Pardo, José L. +1 more
openaire +2 more sources
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Right orthogonal class of pure projective modules over pure hereditary rings
, 2020 Let $\mathcal{W}$ be the class of all pure projective modules. In this article, $\mathcal{W}$-injective modules is defined via the vanishing of cohomology of pure projective modules.
Arunachalam, Umamaheswaran +1 more
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