Results 121 to 130 of about 40,981 (269)

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

open access: yesMedicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman   +6 more
wiley   +1 more source

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

open access: yesAnimal Research and One Health, EarlyView.
Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardize the health and safety of animals and human beings. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induction. The virulence and protective efficacy of RA343 were subsequently assessed. Overall, the RA343 strain is a promising novel
Linjiao Li   +12 more
wiley   +1 more source

The Value Chain of Sustainable Dual Carbon Sodium Ion Capacitors

open access: yesBatteries &Supercaps, EarlyView.
Sodium‐ion capacitors (SICs) bridge the energy‐power gap between batteries and supercapacitors, offering sustainable and scalable energy storage solutions. This review provides a 360‐degree perspective on SIC technology, covering material choices, presodiation strategies, manufacturing challenges, applications and life cycle assessment to ensure ...
Roman Mysyk   +23 more
wiley   +1 more source

Functional and structural markers of peripheral microvascular autonomic neuropathy

open access: yesMuscle &Nerve, Volume 67, Issue 2, Page 146-153, February 2023., 2023
Abstract Introduction/Aims Autonomic dysfunction is a common complication of small‐fiber neuropathy (SFN). In this study we aimed to assess the applicability of autonomic microvascular indices as a potential marker for SFN assessment. Methods Fifteen patients with confirmed SFN (idiopathic neuropathy [n = 10], chemotherapy‐induced peripheral neuropathy
Thorsten K. Rasmussen   +5 more
wiley   +1 more source

Advancements in Silicon Anodes for Enhanced Lithium‐Ion Batteries Performance: Innovations Toward Next‐Gen Superbatteries

open access: yesBattery Energy, EarlyView.
Advancing Anode Materials for Next‐Generation Energy Storage Applications. ABSTRACT Silicon (Si)‐based materials have emerged as promising alternatives to graphite anodes in lithium‐ion (Li‐ion) batteries due to their exceptionally high theoretical capacity.
Norshahirah Mohamad Saidi   +5 more
wiley   +1 more source

Community and Consumer Dynamics in NFTs: Understanding Digital Asset Value Through Social Engagement

open access: yesJournal of Consumer Behaviour, EarlyView.
ABSTRACT While non‐fungible tokens (NFTs) have emerged as a significant blockchain application, research has largely focused on market dynamics rather than consumer behavior. Through in‐depth interviews with 21 NFT consumers and a netnographic analysis of Discord interactions (109,517 words), this study develops a comprehensive framework explaining the
Kristina Brahmstaedt
wiley   +1 more source

Ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology of the subfamily Gomphrenoideae (Amaranthaceae): A comprehensive review

open access: yesChemistry &Biodiversity, Accepted Article.
The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates

open access: yesChemMedChem, EarlyView.
Antibody‐drug conjugates (ADCs) have emerged as a powerful form of targeted therapeutic. However, despite the myriad methods to generate even‐integer drug‐to‐antibody ratio (DAR) ADCs, strategies to generate DAR 1 are seldom reported despite the property tuning advantages of low drug loading or in enabling access to antibody‐protein constructs.
Thomas Wharton, David R. Spring
wiley   +1 more source

Midodrine Causes Forearm Vasoconstriction During Cycling in Patients with Pure Autonomic Failure

open access: bronze, 2004
William G. Schrage   +6 more
openalex   +2 more sources

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