Results 31 to 40 of about 96,540 (233)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Energy efficiency evaluation of construction projects using data envelopment analysis and Tobit regression

Scientific Reports
Energy efficiency (EE) in the construction sector is crucial for sustainable development, particularly in emerging economies like Pakistan, where the industry accounts for a large share of energy consumption and environmental degradation.
Muzaffar Iqbal, Junhai Ma, Zulqarnain Mushtaq, Naveed Ahmad, Muhammad Zain Yousaf, Bashar Tarawneh, Wajid Khan, Mukesh Pushkarna, Ievgen Zaitsev   +8 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Green credit operation performance evaluation of commercial banks in the context of epidemic and carbon reduction

Energy Exploration & Exploitation, 2023
As the world is paying increasing attention to carbon reduction, this paper uses Chinese commercial banks’ green credit and applies the DEA-Malmquist index method to construct an evaluation index system based on the panel data of the top 10 Chinese banks
Wentsao Pan, Zhonghuan Wu, Wenxuan Shen, Chan Wen, Ziqi Li, Xiuli Liao, Menglei Wu   +6 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Technical Efficiency of Indonesian Commercial Banks: An Application of Two-Stage DEA

Jurnal Manajemen dan Wirausaha, 2011
This paper uses data envelopment analysis (DEA) to investigate the technical efficiency of the Indonesian commercial banks over the period 2004-2009 using intermediation approach.
Tessa Vanina Soetanto, Ricky .
doaj  

Does production mode matter for technology efficiency? Evidence from rice-crayfish co-culture and monoculture systems in Hubei, China

Frontiers in Sustainable Food Systems
IntroductionImproving technical efficiency in rice production is critical for balancing food security with environmental sustainability, particularly in developing countries where fragmented farmland and intensive input use pose dual challenges ...
Gantian Zheng, Weiwei Wang, Chang Jiang, Fan Jiang   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source