Results 51 to 60 of about 90,493 (233)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Does Africa’s natural resource impact Chinese enterprise FDI efficiency? A DEA-Tobit model
Future Business JournalThis study investigates the effectiveness of foreign direct investment (FDI) by Chinese enterprises in Africa and how the natural resources of the continent influence this effectiveness.
Priscilla Nyamekye Abban +2 more
doaj +1 more source
Efficiency Evaluation of the Integrated Medical and Nursing Care Services in Beijing's Nursing Homes [PDF]
Zhongguo quanke yixueBackground The degree of aging in China is constantly deepening, and the demand for medical and nursing care services among residents is increasing day by day.
ZHU Lili, HAO Xiaoning, ZHENG Yanhui, LIU Zhi, ZHOU Yuchen
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Energies, 2020 Coal is the primary source of energy in India. Despite being the second-largest coal-producingcountry, there exists a significant difference in demand and production in India.
Biswaranjita Mahapatra +2 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The effect of work accidents on the efficiency of production in the coal sector
South African Journal of Science, 2011 In comparison with other sectors, mining is one of the sectors with the highest rates of work accidents. Such accidents negatively affect a country's economy by wasting domestic resources and causing losses of both labour force and working days.
Ya şar Kasap
doaj
Estimating regional coal resource efficiency in China using three-stage DEA and bootstrap DEA models
International Journal of Mining Science and Technology, 2015 Based on three-stage data envelopment analysis (DEA) model estimates of resource utilization efficiency of coal, we selected 29 provinces from China’s 2012 input–output data and used the bootstrap DEA model to correct the bias.
Yijia Cui, Guoliang Huang, Ziyong Yin
doaj +1 more source