Results 61 to 70 of about 94,118 (277)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Estimating regional coal resource efficiency in China using three-stage DEA and bootstrap DEA models
International Journal of Mining Science and Technology, 2015 Based on three-stage data envelopment analysis (DEA) model estimates of resource utilization efficiency of coal, we selected 29 provinces from China’s 2012 input–output data and used the bootstrap DEA model to correct the bias.
Yijia Cui, Guoliang Huang, Ziyong Yin
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
The effect of work accidents on the efficiency of production in the coal sector
South African Journal of Science, 2011 In comparison with other sectors, mining is one of the sectors with the highest rates of work accidents. Such accidents negatively affect a country's economy by wasting domestic resources and causing losses of both labour force and working days.
Ya şar Kasap
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
BMC Health Services Research, 2017 Background Many large-scaled public hospitals have established branched hospitals in China. This study is to provide evidence for strategy making on the management and development of multi-branched hospitals by evaluating and comparing the operational ...
Tongying Jia, Huiyun Yuan
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Comparison of provincial average pure technical efficiency of 3rd and 1st stage.
, 2023 Comparison of provincial average pure technical efficiency of 3rd and 1st stage.
Jiangwei Ni (17254920) +2 more
core +1 more source
Evaluating Relative Efficiency of Major Cargo Ports in the Middle East: The Integrated DEA-AP Approach [PDF]
مدیریت بهره وری, 2018 The aim of this study was to evaluate the relative efficiency of major cargo ports in Middle East over the three-year period of 2011-2013. The research data were collected from scientific resources and input and output data from statistical yearbook of ...
Azita Hajizadeh +4 more
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