Results 111 to 120 of about 1,178,773 (316)

Expression, solubilisation, and purification of a functional CMP-sialic acid transporter in Pichia pastoris

, 2014
Membrane proteins, including solute transporters play crucial roles in cellular function and have been implicated in a variety of important diseases, and as such are considered important targets for drug development.
Maggioni, Andrea, Hadley, Barbara, von Itzstein, Mark, Tiralongo, Joe   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Affinity purification and elimination of methionine oxidation in recombinant human cystatin C

, 1997
Recombinant human cystatin C (cC), a cysteine protease inhibitor, contained methionine sulfoxide [Met(O)] residues when expressed in Escherichia coli under aerobic conditions or upon allowing osmotic shock solutions from anaerobically grown cultures to ...
Berti, Paul J, Lindahl, Peter, Abrahamson, Magnus, Ekiel, Irena, Lund University., Storer, Andrew C, Abrahamson, Magnus,   +6 more
core   +1 more source

The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum [PDF]

, 2004
The discovery of a potentially novel proline-specific peptidase from bovine serum is presented which is capable of cleaving the dipeptidyl peptidase IV (DPIV) substrate Gly-Pro-MCA.
Buckley, Seamus J., O'Connor, Brendan, O\u27Connor, Brendan, Collins, Patrick   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Potato leafroll virus, its purification from its vector Myzus persicae

, 1967
Experiments were described on the purification of potato leafroll virus (PLRV) from its vector Myzus persicae. Preliminary experiments demonstrated that much non- viral material had to be removed from aphid macerates to obtain a pure virus preparation ...
Peters, D.
core  

Purification-Free MicroRNA Detection by Using Magnetically Immobilized Nanopores on Liposome Membrane

, 2018
MicroRNAs have critical roles in a number of serious diseases and, as a result, are of major interest as clinical diagnostic targets. Conventionally, microRNAs are collected from blood and urine samples and are measured by either quantitative reverse ...
Toshihisa Osaki (605695), Satoshi Fujii, Toshihisa Osaki, Masatoshi Hayakawa (5678810), Koki Kamiya, Nobuo Misawa, Satoshi Fujii (24755), Masatoshi Hayakawa, Shoji Takeuchi (114102), Nobuo Misawa (2183982), Shoji Takeuchi, Koki Kamiya (605693)   +11 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Purification of the Campylobacter jejuni Dps protein assisted by its high melting temperature

, 2015
Dps proteins (DNA binding protein from starved cell) form a distinct group within the ferritin superfamily. All Dps members are composed of 12 identical subunits that assemble into a conserved spherical protein shell.
Korolik, Victoria, Souza, Emanuel, Moure, Vivian, Pedrosa, Fábio, Moure, Vivian R, Souza, Emanuel M, Huergo, Luciano, Valdameri, Glaucio, Sanchuki, Heloisa BS, Oliveira, Marco A, Huergo, Luciano F, Sanchuki, Heloisa, Pedrosa, Fabio O, Oliveira, Marco   +13 more
core   +1 more source

Purification of Ampicillin [PDF]

BMJ, 1970
G T, Stewart, B T, Butcher, R, Zemelman
openaire   +2 more sources