Results 91 to 100 of about 1,178,773 (316)

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report

BMC Nephrology, 2019
Background Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy.
Tadasu Kojima, Go Hirose, Shuuhei Komatsu, Taito Oshima, Kentaro Sugisaki, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada, Takashi Oda   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Neutrophil Percentage-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Maintenance Hemodialysis Patients

International Journal of General Medicine
Changjing Shi,1,* Juan Wang,2,* Weichen Liu,2 Yiyi Mo,2 Yuan Huang,2 Xiaoxiao Wei,2 Dongmei Huo,2,* Aifang Huang2,* 1Information Technology Center, The First Affiliated Hospital of Guangxi Medical University, Nanning ...
Shi C, Wang J, Liu W, Mo Y, Huang Y, Wei X, Huo D, Huang A   +7 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Fast purification of the Apo form and of a non-binding heme mutant of recombinant sperm whale myoglobin

, 2015
As molecular biology has developed it has become possible to abundantly produce heterologous proteins in bacteria and to design serial amino acid substitutions for the generation of modified proteins, an approach also known as protein engineering.
Regis, WCB, Tasic, L, Ribeiro, EA, Ramos, CHI   +3 more
core   +1 more source

Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients

Renal Failure
Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial.
Wanqing Huang, Jiuxu Bai, Yanping Zhang, Dongxia Qiu, Lin Wei, Chen Zhao, Zhuo Ren, Qian Wang, Kaiming Ren, Ning Cao   +9 more
doaj   +1 more source

The effect of the erythropoietin resistance index on brain hemorrhage and infarction risk in maintenance hemodialysis patients: a retrospective cohort study [PDF]

PeerJ
Background Maintenance hemodialysis (MHD) is the main renal replacement therapy for patients with end-stage renal disease, and erythropoietin (EPO) is the main therapy for renal anemia in patients receiving maintenance hemodialysis. However, the risks of
Mingyu Liu, Kaiming Ren, Qian Wang, Chen Zhao, Zhuo Ren, Jiuxu Bai, Ning Cao   +6 more
doaj   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A novel approach for the production and purification of mannosylerythritol lipids (MEL) by Pseudozyma tsukubaensis using cassava wastewater as substrate [PDF]

, 2017
P. tsukubaensis is a yeast-like microorganism that synthesized the biosurfactant mannosylerythritol lipids-B (MEL-B). Production cost can be one of the drawbacks of biosurfactants production.
Cristiano José de Andrade, Mauricio Luis; Pastore, Glaucia Maria; Jauregi, Sforça, Mauricio Luis, Pastore, Gláucia Maria, Silvana Aparecida; Sforca, Lidiane Maria de Andrade, De Andrade, Cristiano José, Rocco, Silvana Aparecida, Paula, Gláucia Maria Pastore, Mauricio Luis Sforça, Silvana Aparecida Rocco, Lidiane Maria; Rocco, Cristiano Jose; de Andrade, Jauregi, Paula, De Andrade, Lidiane Maria, Paula Jauregi, de Andrade   +18 more
core   +1 more source