Results 71 to 80 of about 1,326,906 (303)

Cardiac valve calcification and risk of cardiovascular or all-cause mortality in dialysis patients: a meta-analysis

BMC Cardiovascular Disorders, 2018
Background Vascular calcification is a risk factor for the pathogenesis of cardiovascular disease and mortality in dialysis patients. Nevertheless, the association between cardiac valve calcification (CVC) and the outcome of dialysis is still illusive ...
Zhe Wang, Aili Jiang, Fang Wei, Haiyan Chen   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Association between the serum uric acid-to-creatinine ratio and cardiovascular mortality in maintenance hemodialysis patients

Renal Failure
Background Uric acid is a risk factor for death in hemodialysis patients, but its exact role is still unclear. The serum uric acid-to-serum creatinine (SUA/SCr) ratio is a new indicator. This study aimed to clarify the relationship between this indicator
Wanqing Huang, Ning Ding, Yanping Zhang, Dongxia Qiu, Lin Wei, Chen Zhao, Zhuo Ren, Qian Wang, Kaiming Ren, Jiuxu Bai, Ning Cao   +10 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

High-yield expression and purification of a monotopic membrane glycosyltransferase

, 2009
Membrane proteins are essential to many cellular processes. However, the systematic study of membrane protein structure has been hindered by the difficulty in obtaining large quantities of these proteins.
Eriksson, Hanna M, Eriksson, Hanna M.,, Zhang, Shuguang, Wieslander, Åke,, Persson, Karina,, Zhang, Shuguang,, Wieslander, Åke   +6 more
core   +1 more source

Developing Dietary Self-Management Personas for mHealth Tools Among Patients with Kidney Failure Undergoing Hemodialysis: A Multi-Method Study

Patient Preference and Adherence
Zhishan Wu, Yuefeng Ding, Beiqian Tong, Sijie Gao, Jiayi HuangDepartment of Blood Purification, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Jiayi Huang, Email gongzuo610@126 ...
Wu Z, Ding Y, Tong B, Gao S, Huang J
doaj  

The DYRK Family: A Key Regulator of Metabolic Homeostasis and Its Therapeutic Potential in Kidney Diseases

MedComm – Future Medicine
The dual‐specificity tyrosine‐regulated kinase (DYRK) family, a conserved serine/threonine kinase group, plays a pivotal role in the regulation of metabolic homeostasis by modulating glucose/lipid metabolism, oxidative stress, and calcium‐phosphorus ...
Yixuan Zhu, Pengfei Qiao, Yukun Gan, Xiushuo Fu, Xiayue Huang, Sirui Sun, Yafei Gou, Wenjie Xia, Feng Ma, Limin Liu   +9 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Development and Validation of a Risk Prediction Model for Interdialytic Hyperkalemia in Patients Undergoing Maintenance Hemodialysis

Risk Management and Healthcare Policy
Pan Wang,1,* Jun-Nan Xiao,1,* Yan-Yu Liu,2 Long Xiao,1 Jie-Li Chen,1 Yu Wang,1 Li-Hua Yang,3 Xiu-Li Feng4 1Blood Purification Centre, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510000, People’s Republic of ...
Wang P, Xiao JN, Liu YY, Xiao L, Chen JL, Wang Y, Yang LH, Feng XL   +7 more
doaj  

Molecular mechanisms of hydrogen sulfide against uremic accelerated atherosclerosis through cPKCβII/Akt signal pathway

BMC Nephrology, 2019
Background Cardiovascular disease is the most common complication and leading cause of death in maintenance hemodialysis patients. The protection mechanism of hydrogen sulfide (H2S) and the specific role of conventional protein kinase C βII (cPKCβII)/Akt
Ruifang Xiong, Xiangxue Lu, Jinghong Song, Han Li, Shixiang Wang   +4 more
doaj   +1 more source