Results 51 to 60 of about 1,326,906 (303)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Latent profiles of falls self-awareness and associated factors in older maintenance hemodialysis patients

Scientific Reports
Falls are a significant concern for elderly Maintenance Hemodialysis (MHD) patients, with a rising fall-related mortality rate observed over the past decade.
Jun Xu, Suping Guo, Xintao Yu, Xiaojing Ji   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Conservative kidney management in a young patient with severe intellectual disability: clinical implications for kidney therapy decision-making - a case report

BMC Nephrology
Background Conservative kidney management (CKM) is increasingly recognized as a patient-centered treatment pathway for individuals with advanced chronic kidney disease (CKD).
Hajime Hirano, Tomohisa Matsunaga, Takahiro Inoue, Yu Munakata, Tetsuro Machimura, Tatsuhiko Mori, Haruhito Azuma, Norio Hanafusa   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analysis of the mediating effect of social status perception on professional identity and work engagement of blood purification nurses

Scientific Reports
To explore the relationship between social status perception, professional identity, and work engagement among nurses involved in blood purification, and to provide a theoretical basis for improving the professional identity and work engagement of blood ...
Jia Wanning, Dong Wan, Fan Xueting, Gao Liqian, He Wenwen   +4 more
doaj   +1 more source

Role of the newly established Renal Replacement Therapy Professional Instructor in Japan and the future direction of renal replacement therapy

Renal Replacement Therapy, 2023
Approximately 340,000 people in Japan are on chronic dialysis, and this number continues to increase. Even today, hemodialysis is the most frequently selected modality for renal replacement therapy in Japan, accounting for approximately 97% of chronic ...
Yuki Kawaguchi, Norio Hanafusa, Ken Tsuchiya   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Characterizing natural separation and purification during rural polluted water self-purification in the Dashi River: a multidimensional approach to DOM and microbial interactions

The self-purification capacity of rivers, a natural analog to engineered separation processes, mitigates pollutants through complex physicochemical and biological interactions.
Graham, Nigel, Sun, Kening, Xie, Jin, Yu, Wenzheng, Liu, Ting   +4 more
core   +1 more source