Results 31 to 40 of about 1,178,773 (316)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

A propos de la diversité du monde microbien

open access: yes, 2006
López-Garcia Purification. A propos de la diversité du monde microbien. In: Bulletin de la Classe des sciences, tome 17, n°1-6, 2006. pp.
López-Garcia, Purification   +1 more
core   +1 more source

Hepatitis C virus and carpal tunnel syndrome in hemodialysis patients: a single center cross-sectional study

open access: yesRenal Failure, 2020
Objectives Carpal tunnel syndrome (CTS) is a common complication in maintenance hemodialysis (MHD) patients and leads to disabilities and increased risk of mortality. Hepatitis C virus (HCV) infection is associated with inflammatory and oxidative stress,
Ling Yu   +5 more
doaj   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm   +11 more
wiley   +1 more source

Orthogonal Protein Purification - Expanding the Repertoire of GST Fusion Systems

open access: yes, 2008
We have previously developed a labeling scheme that can be used to site-specifically link human glutathione transferases (hGSTs) from the alpha class to chemical entities such as fluorophores and aldehydes.
Viljanen, Johan,   +5 more
core   +1 more source

Scalable diafiltration process for the purification of a colloidal dispersion of ultrasmall iron (oxyhydr)oxide-based nanoparticles

open access: yes, 2023
The process description for large-scale production of iron (oxyhydr)oxide nanoparticles is currently receiving greater attention, with cost-effective industrial production usually crucial for economic application.
Sebastian Patrick Schwaminger   +9 more
core   +1 more source

Circ_0114428 promotes proliferation, fibrosis and EMT process of high glucose-induced glomerular mesangial cells through regulating the miR-185-5p/SMAD3 axis

open access: yesAutoimmunity, 2022
Circular RNA (circRNA) has been confirmed to be the key regulators of diabetic nephropathy (DN) progression. However, the role of circ_0114428 in the DN progression remains unclear. Glomerular mesangial cells (GMCs) were treated with high glucose (HG) to
Bo Li   +4 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási   +14 more
wiley   +1 more source

High-throughput production of human proteins for crystallization: the SGC experience.

open access: yes, 2010
Producing purified human proteins with high yield and purity remains a considerable challenge. We describe the methods utilized in the Structural Genomics Consortium (SGC) in Oxford, resulting in successful purification of 48% of human proteins attempted;
Savitsky, P   +24 more
core   +1 more source

Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult

open access: yesScientific Reports, 2023
As a leading cause of chronic kidney disease, diabetic kidney disease (DKD) involves insidious but progressive impairments of renal tubules, and is associated with premature renal aging. The underlying pathomechanisms remain elusive. Post hoc analyses of
Bo Han Chen   +3 more
doaj   +1 more source

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