Results 121 to 130 of about 20,168 (266)
FoodsIn this study, we investigated the effects of air packaging, vacuum packaging and modified atmosphere packaging (CO2/N2: 80/20) on the purine metabolism and enzyme activities of refrigerated large yellow croakers.
Tiansheng Xu +4 more
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An Efficient Chemoenzymatic Process for Preparation of Ribavirin
International Journal of Chemical Engineering, 2015 Ribavirin is an important antiviral drug, which is used for treatment of many diseases. The pilot-scale chemoenzymatic process for synthesis of the active pharmaceutical ingredient Ribavirin was developed with 32% overall yield and more than 99.5% purity.
Vladimir Sakharov +4 more
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Терапевтический архив, 2010 Aim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. Materials and methods.
Aleksandr Borisovich Zborovskiy +11 more
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Scientific ReportsChronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are difficult to treat, and therapies are limited in number and efficacy.
Lori A. Birder +6 more
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Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
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Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimurium [PDF]
, 1975 Kaj Frank Jensen, Per Nygaard
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Molecules, 2019 Purine isosteres present excellent opportunities in drug design and development. Using isosteres of natural purines as scaffolds for the construction of new therapeutic agents has been a valid strategy of medicinal chemistry.
Ahmad Junaid +4 more
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, 2014 The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan +2 more
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Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency [PDF]
, 1978 Amos Cohen +4 more
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Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase
Pharmaceutical and Biomedical Research, 2019 Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi +9 more
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