Results 121 to 130 of about 24,465 (266)

Nucleotide degradation and ribose salvage in yeast

Molecular Systems Biology, 2013
Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway.
Yi‐Fan Xu, Fabien Létisse, Farnaz Absalan, Wenyun Lu, Ekaterina Kuznetsova, Greg Brown, Amy A Caudy, Alexander F Yakunin, James R Broach, Joshua D Rabinowitz   +9 more
doaj   +1 more source

Enzymatic Synthesis of Highly Fluorescent 8-Azapurine Ribosides Using a Purine Nucleoside Phosphorylase Reverse Reaction: Variable Ribosylation Sites

Molecules, 2013
Various forms of purine-nucleoside phosphorylase (PNP) were used as catalysts of enzymatic ribosylation of selected fluorescent 8-azapurines. It was found that the recombinant calf PNP catalyzes ribosylation of 2,6-diamino-8-azapurine in a phosphate-free
Goran Mikleušević, Alicja Stachelska-Wierzchowska, Beata Wielgus-Kutrowska, Jacek Wierzchowski   +3 more
doaj   +1 more source

An Efficient Chemoenzymatic Process for Preparation of Ribavirin

International Journal of Chemical Engineering, 2015
Ribavirin is an important antiviral drug, which is used for treatment of many diseases. The pilot-scale chemoenzymatic process for synthesis of the active pharmaceutical ingredient Ribavirin was developed with 32% overall yield and more than 99.5% purity.
Vladimir Sakharov, Sergey Baykov, Irina Konstantinova, Roman Esipov, Mikhail Dorogov   +4 more
doaj   +1 more source

Site-Selective Ribosylation of Fluorescent Nucleobase Analogs Using Purine-Nucleoside Phosphorylase as a Catalyst: Effects of Point Mutations

Molecules, 2015
Enzymatic ribosylation of fluorescent 8-azapurine derivatives, like 8-azaguanine and 2,6-diamino-8-azapurine, with purine-nucleoside phosphorylase (PNP) as a catalyst, leads to N9, N8, and N7-ribosides.
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Agnieszka Bzowska, Beata Wielgus-Kutrowska   +3 more
doaj   +1 more source

Purine and Pyrimidine Salvage in Whole Rat Brain. Utilization of ATP-derived Ribose-1-Phosphate and 5-Phosphoribosyl-1-pyrophosphate Generated in Experiments with Dialyzed Cell-free Extracts [PDF]

, 2002
The object of this work stems from our previous studies on the mechanisms responsible of ribose-1-phosphate- and 5-phosphoribosyl-1-pyrophosphate-mediated nucleobase salvage and 5-fluorouracil activation in rat brain (Mascia, L., Cappiello M., Cherri, S.,
BARSOTTI C, IPATA, PIERO LUIGI, TOZZI, MARIA GRAZIA   +2 more
core   +1 more source

Altered purine and pyrimidine metabolism in erythrocytes with purine nucleoside phosphorylase deficiency [PDF]

, 1980
Purine and pyrimidine metabolism was compared in erythrocytes from three patients from two families with purine nucleoside phosphorylase deficiency and T-cell immunodeficiency, one heterozygote subject for this enzyme deficiency, one patient with a ...
A. Cohen, A. Cohen, A. Cohen, A. Cohen, A. S. Bagnara, A. S. Bagnara, D. P. Brenton, E. Kaukel, E. R. Giblett, E. R. Giblett, E. W. Gelfand, E. W. Gelfand, F. F. Snyder, F. F. Snyder, F. M. Rosenbloom, F. M. Rosenbloom, G. Nuki, G. Planet, H. Green, H. Hilz, H. J. Meuwissen, I. H. Fox, I. H. Fox, I. H. Fox, I. H. Fox, I. H. Fox, I. H. Fox, I. H. Fox, I. H. Fox, J. E. Seegmiller, J. F. Henderson, J. F. Henderson, J. W. Stoop, K. C. Rich, K. Ishii, L. H. Siegenbeek van Heukelom, M. Hamet, M. Lesch, M. S. Coleman, N. L. Edwards, N. L. Edwards, O. H. Lowry, P. S. Chen Jr., R. D. Agarwal, R. L. Wortmann, T. D. Beardmore, W. B. Weyden Van der, W. N. Kelley, W. N. Kelley, Y. H. Edwards   +49 more
core   +1 more source

Fused Heterocyclic Systems with an s-Triazine Ring. 34. Development of a Practical Approach for the Synthesis of 5-Aza-isoguanines

Molecules, 2019
Purine isosteres present excellent opportunities in drug design and development. Using isosteres of natural purines as scaffolds for the construction of new therapeutic agents has been a valid strategy of medicinal chemistry.
Ahmad Junaid, Felicia Phei Lin Lim, Yvonne Peijun Zhou, Wai Keung Chui, Anton V. Dolzhenko   +4 more
doaj   +1 more source

Recent advances in structure and function of cytosolic IMP-GMP specific 5′nucleotidase II (cN-II) [PDF]

, 2006
Cytosolic 5′nucleotidase II (cN-II) catalyses both the hydrolysis of a number of nucleoside monophosphates (e.g., IMP + H2O→inosine + Pi), and the phosphate transfer from a nucleoside monophosphate donor to the 5′position of a nucleoside acceptor (e.g ...
A Rinaldo-Matthis, AG Chapman, AG Zimmermann, AS Bretronnet, B Setlow, C Baiocchi, C Barsotti, C Barsotti, C Barsotti, C Barsotti, C Barsotti, C Latini, CM Galmarini, CM Galmarini, D Cao, G Berghe Van den, HG Markley, J Barankiewicz, JF Collet, JW Phillis, KW Pankiewicz, L Aravind, L Mascia, L Mascia, L Mascia, M Pak, M Turriani, MA Becker, MA Johnson, Maria Grazia Tozzi, MG Tozzi, PA Berman, Piero Luigi Ipata, R Itoh, R Itoh, R Itoh, R Itoh, R Pesi, RM Leach, RM Pinto, S Allegrini, S Allegrini, S Banditelli, S Latini, V Bianchi, W Wang, Y Worku   +46 more
core   +2 more sources

The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis

Терапевтический архив, 2010
Aim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. Materials and methods.
Aleksandr Borisovich Zborovskiy, Elena Eduardovna Mozgovaya, Vladislav Fedorovich Martem'yanov, Ol'ga Petrovna Slyusar', Mikhail Yur'evich Stazharov, S A Bedina, A B Zborovsky, E E Mozgovaya, V F Martemyanov, O P Slyusar, M Yu Stazharov, S A Bedina   +11 more
doaj  

Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. [PDF]

Arch Iran Med, 2023
Alizadeh Z, Badalzadeh M, Heydarlou H, Shakerian L, Mahlooji Rad M, Zandieh F, Fazlollahi MR.   +6 more
europepmc   +1 more source