Results 121 to 130 of about 14,313 (250)

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Pharmaceutical and Biomedical Research, 2019
Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash   +9 more
doaj  

Purine nucleoside phosphorylase deficiency [PDF]

, 2020
  +5 more sources

Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]

, 1987
Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core  

Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells [PDF]

, 2017
Patricia Giuliani, Mariachiara Zuccarini, Silvana Buccella, Emiliano Peña‐Altamira, Elisabetta Polazzi, Marco Virgili, Barbara Monti, Alessandro Poli, Michel P. Rathbone, Patrizia Di Iorio, Renata Ciccarelli, Francesco Caciagli   +11 more
openalex   +1 more source

Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. [PDF]

Arch Iran Med, 2023
Alizadeh Z, Badalzadeh M, Heydarlou H, Shakerian L, Mahlooji Rad M, Zandieh F, Fazlollahi MR.   +6 more
europepmc   +1 more source

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

, 2017
Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer.
Agirre, Xabier, Apaolaza, Iñigo, Atauri, Pedro de, Carracedo, Arkaitz, Cascante i Serratosa, Marta, Cendoya, Xabier, Garate, Leire, Miranda, Estíbaliz, Ochoa, María Carmen, Pey, Jon, Planes, Francisco J., Prosper, Felipe, Rubio, Angel, San José-Eneriz, Edurne   +13 more
core   +3 more sources

A trimeric structure for mammalian purine nucleoside phosphorylase [PDF]

, 1973
Yvonne H. Edwards, Paul A. Edwards, D. A. HOPKINSON   +2 more
openalex   +1 more source

The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a `spanner in the works'. [PDF]

Acta Crystallogr F Struct Biol Commun, 2022
Given FM, Moran F, Johns AS, Titterington JA, Allison TM, Crittenden DL, Johnston JM.   +6 more
europepmc   +1 more source

Creation of strain – producer of bacterial purine nucleoside phosphorylase fused with human annexin A5

, 2020
A. B. Bulatovski, А. И. Зинченко   +1 more
openalex   +2 more sources

Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]

J Phys Chem B, 2023
Frost CF, Balasubramani SG, Antoniou D, Schwartz SD.   +3 more
europepmc   +1 more source