Results 111 to 120 of about 12,753 (213)

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]

Nat Rev Urol, 2022
Birder LA, Jackson EK.
europepmc   +1 more source

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. [PDF]

J Med Chem, 2023
Skácel J, Djukic S, Baszczyňski O, Kalčic F, Bílek T, Chalupský K, Kozák J, Dvořáková A, Tloušt'ová E, Král'ová Z, Šmídková M, Voldřich J, Rumlová M, Pachl P, Brynda J, Vučková T, Fábry M, Snášel J, Pichová I, Řezáčová P, Mertlíková-Kaiserová H, Janeba Z.   +21 more
europepmc   +1 more source

Purine Nucleoside Phosphorylase Deficiency [PDF]

Journal of Clinical Investigation, 1977
William R. A. Osborne, Shi-Han Chen, Eloise R. Giblett, W. Douglas Biggar, Arthur A. Ammann, C. Ronald Scott   +5 more
openaire   +1 more source

Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation

Gut Microbes
Gut microbiota dysbiosis has been implicated in the pathogenesis of irritable bowel syndrome (IBS), a globally prevalent functional gastrointestinal disorder; however, mechanistic insights remain limited.
Songyuan Hou, Tingting Ning, Si Liu, Xinyi Yang, Haozhen Ye, Yesheng Zhou, Chenxu Wang, Jiaqi Zhu, Shaochong Lu, Nan Zhang, Shengtao Zhu   +10 more
doaj   +1 more source

Correction: The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. [PDF]

PLoS Pathog, 2022
Tecle E, Chhan CB, Franklin L, Underwood RS, Hanna-Rose W, Troemel ER.   +5 more
europepmc   +1 more source

Trimeric Architecture Ensures the Stability and Biological Activity of the Calf Purine Nucleoside Phosphorylase: In Silico and In Vitro Studies of Monomeric and Trimeric Forms of the Enzyme. [PDF]

Int J Mol Sci, 2023
Dyzma A, Wielgus-Kutrowska B, Girstun A, Matošević ZJ, Staroń K, Bertoša B, Trylska J, Bzowska A.   +7 more
europepmc   +1 more source

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. [PDF]

, 2018
The Hsp90 molecular chaperones are ATP-dependent enzymes that maintain protein homeostasis and regulate many essential cellular processes. Higher eukaryotes have organelle-specific Hsp90 paralogs that are adapted to each subcellular environment.
Agard, David A, Elnatan, Daniel
core  

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source

Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]

Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes, Anibal, Fernanda de Freitas, Correia, Ricardo de Oliveira, Dejani, Naiara Naiana, Garratt, Richard Charles, Neris, Débora Meira, Oliveira, Sandra Regina Pereira de, Pereira, Humberto D'Muniz, Rodolpho, Joice Margareth de Almeida, Rodrigues, Vanderlei, Souza, Laís Cristina de   +10 more
core  

Purine Nucleoside Phosphorylase [PDF]

, 2020
openaire   +1 more source