Results 1 to 10 of about 157,697 (307)

From Gut Homeostasis to Colorectal Cancer: Spatial and Temporal Reprogramming of Microbial Inosine Signaling [PDF]

Biomedicines
Microbial metabolites are increasingly recognized as critical regulators of gut homeostasis, mediating the interaction among gut microbiota, host tissue, and immune response.
Lorenzo Tomassini, Teresa Pacifico, Giovanni Monteleone, Carmine Stolfi, Federica Laudisi   +4 more
doaj   +2 more sources

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Frontiers in Immunology, 2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Wenkai Ren, Xingguo Huang
exaly   +3 more sources

Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Molecules, 2023
Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit   +9 more
doaj   +1 more source

Comparative study and relationship analysis between purine content, uric acid, superoxide dismutase, and growth traits in purebred and crossbred Thai native chickens

Frontiers in Veterinary Science, 2023
The objective was to compare and analyze the relationship between growth, purine content, uric acid, and superoxide dismutase (SOD) in purebred and crossbred Thai native chickens. A total of 300 Thai native chickens were divided into 3 groups.
Veeraya Tantiyasawasdikul, Kitsadee Chomchuen, Wipas Loengbudnark, Vibuntita Chankitisakul, Vibuntita Chankitisakul, Wuttigrai Boonkum, Wuttigrai Boonkum   +6 more
doaj   +1 more source

The influence of the addition of polymers on the physico-chemical properties of bentonite suspensions [PDF]

Science of Sintering, 2014
Bentonite clays have many applications in industries ranging from construction to cosmetics. Addition of polymers can profoundly influence the properties of bentonite suspensions and we now describe the influence of a range of different polymers.
Stojiljkovic S., Miljkovic V., Nikolic G., Kostic D., Arsic B., Barber J., Savic I., Savic I.   +7 more
doaj   +1 more source

Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

eLife, 2020
Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
doaj   +1 more source

The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine

mBio, 2023
Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng, Shannon K. Chang, Daniel A. Portnoy   +2 more
doaj   +1 more source

Ferrocenoyl-adenines: substituent effects on regioselective acylation

Beilstein Journal of Organic Chemistry, 2022
A series of N6-substituted adenine–ferrocene conjugates was prepared and the reaction mechanism underlying the synthesis was explored. The SN2-like reaction between ferrocenoyl chloride and adenine anions is a regioselective process in which the product ...
Mateja Toma, Gabrijel Zubčić, Jasmina Lapić, Senka Djaković, Davor Šakić, Valerije Vrček   +5 more
doaj   +1 more source

Assessment of the temporal trend and daily profiles of the dietary purine intake among Chinese residents during 2014 to 2021

Frontiers in Nutrition, 2023
The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li, Xin Liu, Xiwu Jia, Min Fang, Qing Yang, Zhiyong Gong   +5 more
doaj   +1 more source

Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Frontiers in Pharmacology, 2022
Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang, Yue Zhu, Zhiyuan Zhao, Jintong Du, Xinying Yang, Hao Fang, Xuben Hou   +6 more
doaj   +1 more source