Results 1 to 10 of about 304,542 (327)

A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma

Frontiers in Genetics, 2022
Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods ...
Shengjie Yang, Baoying Zhang, Weijuan Tan, Lu Qi, Xiao Ma, Xinghe Wang   +5 more
doaj   +1 more source

Can adenine nucleotides predict primary nonfunction of the human liver homograft? [PDF]

, 1994
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction.
Bronsther, O, Fujita, S, Hamamoto, I, Irish, W, Nakamura, K, Starzl, TE, Takaya, S, Todo, S, Van Gulik, TM   +8 more
core   +1 more source

An Enterococcus faecalis isolate harboring both aerobic and anaerobic uric acid metabolic pathways alleviates hyperuricemia in mice

Food Science and Human Wellness
Probiotics have been demonstrated to be effective and safe for hyperuricemia (HUA) and gout treatment. Hence, identifying microbes with high uric acid- or purine-metabolizing ability is highly important. Due to the high load of uric acid in chicken feces,
Depeng Li, Xinyue Yang, A La Teng Zhu La, Meihong Zhang, Zhengtian Lü, Yuqing Feng, Dan Liu, Yuming Guo, Yongfei Hu   +8 more
doaj   +1 more source

Purine and pyrimidine bases as growth substances for lactic acid bacteria [PDF]

, 1941
In 1936 Richardson (1) showed that uracil was essential for the anaerobic growth of Staphylococcus aureus, but not for aerobic growth of the same organism.
Mitchell, Herschel K., Snell, Esmond E.
core  

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Cell Reports, 2017
Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis.
G. Hoxhaj, J. Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, J. Asara, I. Ben-Sahra, B. Manning   +7 more
semanticscholar   +1 more source

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions

Molecules
Cancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru), Claudia-Simona Stefan, Aurel Nechita, Madalina-Nicoleta Matei, Elena-Lacramioara Lisa, Dana Tutunaru, Iuliu Fulga, Ana Fulga, Alina-Georgiana Cristea (Hohota), Oana-Maria Dragostin   +9 more
doaj   +1 more source

Comprehensive measurement of purines in biological samples

Frontiers in Analytical Science
Defects in numerous aspects of purine metabolism are well-recognized causes for human diseases. The applicability of ultra performance liquid chromatography (UPLC) with photodiode array (PDA) detection for analysis of the most abundant biological ...
Rong Fu, Diane J. Sutcliffe, Ashok R. Dinasarapu, Ellen J. Hess, Ellen J. Hess, H. A. Jinnah, H. A. Jinnah   +6 more
doaj   +1 more source

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus.
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, N. Friedrich, Julienne C. Kaiser, D. Watson, C. Wilson, J. Sheldon, M. McGavin, P. Kiser, D. Heinrichs   +11 more
semanticscholar   +1 more source

De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues

Journal of Biological Chemistry, 2019
Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues.
T. Fan, Ronald C. Bruntz, Ye Yang, Huan Song, Yelena Chernyavskaya, Pan Deng, Yan Zhang, P. Shah, L. Beverly, Zhen Qi, A. Mahan, R. Higashi, C. Dang, A. Lane   +13 more
semanticscholar   +1 more source

Parallel purine‐pyrimidine‐purine triplex: experimental evidence for existence [PDF]

FEBS Letters, 1995
Oligonucleotides 5′‐d(CT)5‐L‐d(AG)5‐L‐d(GA)5‐3′ and 5′‐d(GA)5‐L‐d(TC)5‐L‐d(GA)5‐3′ [L = pO(CH2CH2O)3p] were studied by thermal denaturation, chemical modification and binding of fluorescent dyes. Both oligonucleotides are shown to fold back on itself twice forming at pH 7 a sufficiently stable triplex ether with antiparallel‐oriented oligopurine ...
Shchyolkina, Anna K., Borisova, Olga F., Minyat, Elvira E., Timofeev, Edward N., Il'icheva, Irina A., Khomyakova, Elena B., Florentiev, Vladimir L.   +6 more
openaire   +2 more sources