Results 21 to 30 of about 157,697 (307)
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]
, 1989 Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland +2 more
core +1 more source
, 2016 Microtubule targeting agents (MTAs) constitute a class of drugs for cancer treatment. Despite many MTAs have been proven to significantly improve the treatment outcomes of various malignancies, resistance has usually occurred.
Pei-Fang Hung (405691) +12 more
core +2 more sources
Frontiers in Pharmacology, 2018 Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and
Yuzo Sato +25 more
doaj +1 more source
MoleculesCancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru) +9 more
doaj +1 more source
Comprehensive measurement of purines in biological samples
Frontiers in Analytical ScienceDefects in numerous aspects of purine metabolism are well-recognized causes for human diseases. The applicability of ultra performance liquid chromatography (UPLC) with photodiode array (PDA) detection for analysis of the most abundant biological ...
Rong Fu +6 more
doaj +1 more source
Altered purine and pyrimidine metabolism in erythrocytes with purine nucleoside phosphorylase deficiency [PDF]
, 1980 Purine and pyrimidine metabolism was compared in erythrocytes from three patients from two families with purine nucleoside phosphorylase deficiency and T-cell immunodeficiency, one heterozygote subject for this enzyme deficiency, one patient with a ...
Fox, Irving H. +2 more
core +1 more source
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
doaj +1 more source
Chemical synthesis of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione (6-TG-Me).
, 2022 (A) 1H NMR spectrum of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione. (B) 13C NMR spectrum of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione. (C) High resolution mass spectrum of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione. (DOCX)
Stephen L. Bearne (1487257) +15 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Synthesis a Number of Triazene Compounds Derived From Purine and Studying their Biological Activity on Pathogenic Bacteria [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2012 In this research a number of compounds were prepared by coupling dizonium salts with purine bases. The structures of the prepared compounds were identified by ultra violet ,infra red spectra and Elemental (C.H.N) analysis .The biological activity of ...
Ahmed .M. Mohamed +2 more
doaj +1 more source