Results 21 to 30 of about 304,542 (327)
Frontiers in Nutrition, 2023 The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li +5 more
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Frontiers in Pharmacology, 2022 Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang +6 more
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Purine metabolism in the development of osteoporosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Osteoporosis is a common bone metabolic disease in postmenopausal women, diabetic patients and obese patients and is characterized by an imbalance in bone formation and resorption.
Keda Yang, Jie Li, Lin Tao
semanticscholar +1 more source
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Science, 2020 Signs of a metabolon in action Eukaryotic cells have a heterogeneous cytoplasm, with compartments large and small, membrane bound or not. Enzymes that catalyze the de novo synthesis of purine nucleotides, which are needed in rapidly dividing cells, are ...
V. Pareek +3 more
semanticscholar +1 more source
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Nature Communications, 2020 Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype are urgently needed.
Weihua Zhou +27 more
semanticscholar +1 more source
The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto de vitto +3 more
semanticscholar +1 more source
Molecules, 2020 Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep +10 more
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Adenosinium 3,5-dinitrosalicylate [PDF]
, 2004 The crystal structure of adenosinium 3,5-dinitrosalicylicate, C10H14N5O4+烷H3N2O7-, shows the presence of a primary chain structure formed through homomeric head-to-tail cyclic R22(10) hydrogen-bonding interactions between hydroxy O- and both purine and ...
Healy, Peter +2 more
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Molecules, 2011 A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and ...
Hosam A. Saad +3 more
doaj +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Wall, Mark J. +2 more
core +2 more sources