Results 21 to 30 of about 245,344 (350)
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
Nature Communications, 2022 Purine nucleotides are necessary for various biological processes related to cell proliferation. Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-dependent reactions, the impact of changes in cellular purine levels on ...
M. H. Soflaee +20 more
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The interaction of aflatoxins with purines and purine nucleosides [PDF]
Biochemical Journal, 1967 From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino ...
J I, Clifford, K R, Rees
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Frontiers in Veterinary Science, 2023 The objective was to compare and analyze the relationship between growth, purine content, uric acid, and superoxide dismutase (SOD) in purebred and crossbred Thai native chickens. A total of 300 Thai native chickens were divided into 3 groups.
Veeraya Tantiyasawasdikul +6 more
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Purine metabolism in the development of osteoporosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Osteoporosis is a common bone metabolic disease in postmenopausal women, diabetic patients and obese patients and is characterized by an imbalance in bone formation and resorption.
Keda Yang, Jie Li, Lin Tao
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Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation
Zoological Research, 2022 Many mammals risk damage from oxidative stress stemming from frequent dives (i.e., cycles of ischemia/reperfusion and hypoxia/reoxygenation), high altitude and subterranean environments, or powered flight.
Ran Tian +5 more
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The influence of the addition of polymers on the physico-chemical properties of bentonite suspensions [PDF]
Science of Sintering, 2014 Bentonite clays have many applications in industries ranging from construction to cosmetics. Addition of polymers can profoundly influence the properties of bentonite suspensions and we now describe the influence of a range of different polymers.
Stojiljkovic S. +7 more
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Disorders of purine biosynthesis metabolism.
Molecular Genetics and Metabolism, 2021 Purines are essential molecules that are components of vital biomolecules, such as nucleic acids, coenzymes, signaling molecules, as well as energy transfer molecules.
Joseph P. Dewulf, S. Marie, M. Nassogne
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Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Science, 2020 Signs of a metabolon in action Eukaryotic cells have a heterogeneous cytoplasm, with compartments large and small, membrane bound or not. Enzymes that catalyze the de novo synthesis of purine nucleotides, which are needed in rapidly dividing cells, are ...
V. Pareek +3 more
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Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Nature Communications, 2020 Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype are urgently needed.
Wei-Hua Zhou +27 more
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Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
eLife, 2020 Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
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