Results 41 to 50 of about 157,697 (307)

Regulating uric acid

eLife
Certain strains of a bacterium found in the gut of some animals, Lactobacillus plantarum, are able to counter hyperuricemia, a condition caused by high levels of uric acid in the blood.
Caihong Hu
doaj   +1 more source

Síntese de proteína microbiana e concentrações de uréia em vacas alimentadas com diferentes fontes de proteína Estimation of microbial protein synthesis and urea nitrogen metabolism in lactating dairy cows fed diets supplemented with different protein sources

Revista Brasileira de Zootecnia, 2006
Foram utilizadas 12 vacas Holandesas puras e mestiças, distribuídas em três quadrados latinos 4 x 4, organizados de acordo com os dias em lactação, com o objetivo de avaliar o efeito de diferentes fontes protéicas sobre a síntese, a eficiência de síntese
Douglas dos Santos Pina, Sebastião de Campos Valadares Filho, Rilene Ferreira Diniz Valadares, Edenio Detmann, José Maurício de Souza Campos, Mozart Alves Fonseca, Rafael Monteiro Araújo Teixeira, André Soares de Oliveira   +7 more
doaj   +1 more source

Structural and Functional Alterations of Gut Microbiota in Males With Hyperuricemia and High Levels of Liver Enzymes

Frontiers in Medicine, 2021
Objective: To investigate the correlation between the structure and function alterations of gut microbiota and biochemical indicators in males with hyperuricemia (HUA) and high levels of liver enzymes, in order to provide new evidences and therapeutic ...
Shifeng Sheng, Jingfeng Chen, Yuheng Zhang, Qian Qin, Weikang Li, Su Yan, Youxiang Wang, Tiantian Li, Xinxin Gao, Lin Tang, Ang Li, Ang Li, Suying Ding   +12 more
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Biological Characteristics of a Probiotic Wickerhamomyces anomalus Isolated from Pickled Vegetables and Its Function in Preventing Hyperuricemia in Mice

Foods
Hyperuricemia (HUA) is a metabolic disorder that can easily lead to gout or kidney disease, and it is believed that it can be treated effectively using probiotics.
Xiqian Tan, Shuaibo Gao, Xiaoxiao Cheng, Lijun You, Xuepeng Li, Jianrong Li   +5 more
doaj   +1 more source

Influência do nitrogênio degradável no rúmen sobre a degradabilidade in situ, os parâmetros ruminais e a eficiência de síntese microbiana em novilhos alimentados com cana-de-açúcar Ruminal degradable nitrogen for steers fed sugar cane: in situ degradability, ruminal parameters and microbial synthesis efficiency

Revista Brasileira de Zootecnia, 2009
Objetivou-se avaliar o efeito da deficiência de nitrogênio degradável no rúmen (NDR), utilizando como volumoso cana-de-açúcar suplementada com uréia, farelo de soja ou farelo de glúten de milho - 60, sobre a eficiência de síntese microbiana e a ...
Roselene Nunes da Silveira, Telma Teresinha Berchielli, Roberta Carrilho Canesin, Juliana Duarte Messana, Juliano José de Resende Fernandes, Alexandre Vaz Pires   +5 more
doaj   +1 more source

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression

Frontiers in Immunology, 2022
ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang, Lingzhu Xie, Xuhong Song, Jing Wang, Xinyan Li, Zhike Lin, Ting Su, Bin Liang, Dongyang Huang, Dongyang Huang   +9 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Digging into biochemical and signal transduction of old drugs: xanthines and their association to cancer [PDF]

ERU Research Journal
The arena of anticancer drug research has identified xanthine derivatives as intriguing molecules with diverse antimutagenic capabilities against a variety of cancer disorders.
Abdalla Mohamed
doaj   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source