Results 41 to 50 of about 245,344 (350)
Nutrients, 2020 Objective: To explore the correlation between purine-rich food intake and hyperuricemia in Chinese adult residents. Method: A cross-sectional study was conducted on the purine-rich food intake of Chinese adult residents based on the China Health and ...
S. Aihemaitijiang +7 more
semanticscholar +1 more source
Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides
Nature, 2020 The nature of the first genetic polymer is the subject of major debate1. Although the ‘RNA world’ theory suggests that RNA was the first replicable information carrier of the prebiotic era—that is, prior to the dawn of life2,3—other evidence implies that
Jian-Feng Xu +8 more
semanticscholar +1 more source
Molecules, 2020 Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep +10 more
doaj +1 more source
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Science, 2019 Conditions right for making nucleosides In the absence of biological catalysts and metabolism, can atmospheric and geochemical processes provide the substrates and conditions required for production of biological molecules? Becker et al.
S. Becker +9 more
semanticscholar +1 more source
Chemical synthesis of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione (6-TG-Me).
, 2022 (A) 1H NMR spectrum of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione. (B) 13C NMR spectrum of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione. (C) High resolution mass spectrum of 2-amino-9-methyl-3,9-dihydro-6H-purine-6-thione. (DOCX)
Stephen L. Bearne (1487257) +15 more
core +1 more source
Altered purine and pyrimidine metabolism in erythrocytes with purine nucleoside phosphorylase deficiency [PDF]
, 1980 Purine and pyrimidine metabolism was compared in erythrocytes from three patients from two families with purine nucleoside phosphorylase deficiency and T-cell immunodeficiency, one heterozygote subject for this enzyme deficiency, one patient with a ...
Fox, Irving H. +2 more
core +1 more source
mTORC1 Induces Purine Synthesis Through Control of the Mitochondrial Tetrahydrofolate Cycle
Science, 2016 Controlling supplies for DNA and RNA synthesis The mTORC1 protein kinase complex regulates anabolic metabolism and coordinates cellular signals that promote growth with availability of required precursor metabolites.
I. Ben-Sahra +4 more
semanticscholar +1 more source
Purine nucleoside phosphorylase deficiency
Atlas of Inherited Metabolic Diseases, 2020 People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar +1 more source
Molecules, 2011 A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and ...
Hosam A. Saad +3 more
doaj +1 more source
, 2016 Microtubule targeting agents (MTAs) constitute a class of drugs for cancer treatment. Despite many MTAs have been proven to significantly improve the treatment outcomes of various malignancies, resistance has usually occurred.
Pei-Fang Hung (405691) +12 more
core +2 more sources