Results 41 to 50 of about 304,542 (327)
Frontiers in Pharmacology, 2018 Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and
Yuzo Sato +25 more
doaj +1 more source
The influence of the addition of polymers on the physico-chemical properties of bentonite suspensions [PDF]
Science of Sintering, 2014 Bentonite clays have many applications in industries ranging from construction to cosmetics. Addition of polymers can profoundly influence the properties of bentonite suspensions and we now describe the influence of a range of different polymers.
Stojiljkovic S. +7 more
doaj +1 more source
Electron transfer driven decomposition of adenine and selected analogs as probed by experimental and theoretical methods [PDF]
, 2018 We report on a combined experimental and theoretical study of electron transfer induced decomposition of adenine and a selection of analogue molecules in collisions with potassium atoms (K).
Bacchus-Montabonel, M.-C. +6 more
core +4 more sources
Rocaglates induce gain-of-function alterations to eIF4A and eIF4F [PDF]
, 2020 Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies.
Baranov, Pavel V. +12 more
core +1 more source
Thermodynamic reaction control of nucleoside phosphorolysis [PDF]
, 2020 Nucleoside analogs represent a class of important drugs for cancer and antiviral treatments. Nucleoside phosphorylases (NPases) catalyze the phosphorolysis of nucleosides and are widely employed for the synthesis of pentose‐1‐phosphates and nucleoside ...
Giessmann, Robert T. +4 more
core +1 more source
Aromatic N versus aromatic F : bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs [PDF]
, 2010 The thermodynamics of base pairing is of fundamental importance. Fluorinated base analogs are valuable tools for investigating pairing interactions. To understand the influence of direct base–base interactions in relation to the role of water, pairing ...
Alrun N. Koller +74 more
core +1 more source
Nutrients, 2020 Objective: To explore the correlation between purine-rich food intake and hyperuricemia in Chinese adult residents. Method: A cross-sectional study was conducted on the purine-rich food intake of Chinese adult residents based on the China Health and ...
S. Aihemaitijiang +7 more
semanticscholar +1 more source
Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
eLife, 2020 Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
doaj +1 more source
Purine nucleoside phosphorylase deficiency
Atlas of Inherited Metabolic Diseases, 2020 People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar +1 more source
Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]
, 1987 Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core +2 more sources