Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]
, 2011 To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi +3 more
core +2 more sources
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Science, 2019 Conditions right for making nucleosides In the absence of biological catalysts and metabolism, can atmospheric and geochemical processes provide the substrates and conditions required for production of biological molecules? Becker et al.
S. Becker +9 more
semanticscholar +1 more source
Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]
, 2017 A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea +2 more
core +1 more source
Cancers, 2020 Body fluids of patients with head and neck squamous cell carcinoma (HNSCC) are enriched in exosomes that reflect properties of the tumor. The aim of this study was to determine whether purine metabolites are carried by exosomes and evaluate their role as
N. Ludwig +4 more
semanticscholar +1 more source
Electron transport chain inhibition increases cellular dependence on purine transport and salvage
Cell MetabolismSUMMARY Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders and ...
Zheng Wu +25 more
semanticscholar +1 more source
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
doaj +1 more source
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Molecules and Cells, 2020 The RAS-ERK/MAPK (RAS-extracellular signal-regulated kinase/mitogen-activated protein kinase) pathway integrates growth-promoting signals to stimulate cell growth and proliferation, at least in part, through alterations in metabolic gene expression ...
Eunus S. Ali +8 more
semanticscholar +1 more source
Role of HIV RNA structure in recombination and speciation: romping in purine A, keeps HTLV away
, 2013 Extreme enrichment of the human immunodeficiency virus (HIV-1) RNA genome for the purine A parallels the mild purine-loading of the RNAs of most organisms.
Forsdyke, Donald R.
core +1 more source
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
Cell, 2020 M. Zaeem Cader1,2,8, Rodrigo Pereira de Almeida Rodrigues1,2,8, James A. West1,2,3,8, Gavin W. Sewell1,2, Muhammad N. Md-Ibrahim1,2, Stephanie Reikine1,4, Giuseppe Sirago1,2, Lukas W.
M. Z. Cader +21 more
semanticscholar +1 more source
MicrobiologyOpen, 2019 This study aimed to evaluate the profiles of Streptococcus thermophilus nutrient requirements to guide the design of media for high cell density culturing. The growth kinetics, physiological state, and nutrient requirement profiles of S.
Gefei Liu +8 more
doaj +1 more source