Results 51 to 60 of about 245,344 (350)

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Frontiers in Pharmacology, 2018
Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and
Yuzo Sato, Yuzo Sato, Yuzo Sato, Yuzo Sato, Shiori Matsuda, Shiori Matsuda, Shiori Matsuda, Ami Maruyama, Ami Maruyama, Joji Nakayama, Joji Nakayama, Joji Nakayama, Tomoyuki Miyashita, Tomoyuki Miyashita, Tomoyuki Miyashita, Hibiki Udagawa, Shigeki Umemura, Kazuyoshi Yanagihara, Atsushi Ochiai, Masaru Tomita, Masaru Tomita, Tomoyoshi Soga, Tomoyoshi Soga, Katsuya Tsuchihara, Hideki Makinoshima, Hideki Makinoshima   +25 more
doaj   +1 more source

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions

Molecules
Cancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru), Claudia-Simona Stefan, Aurel Nechita, Madalina-Nicoleta Matei, Elena-Lacramioara Lisa, Dana Tutunaru, Iuliu Fulga, Ana Fulga, Alina-Georgiana Cristea (Hohota), Oana-Maria Dragostin   +9 more
doaj   +1 more source

Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma

Cancers, 2020
Body fluids of patients with head and neck squamous cell carcinoma (HNSCC) are enriched in exosomes that reflect properties of the tumor. The aim of this study was to determine whether purine metabolites are carried by exosomes and evaluate their role as
N. Ludwig, Delbert G. Gillespie, T. Reichert, E. Jackson, T. Whiteside   +4 more
semanticscholar   +1 more source

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie, Lisa C Ranford-Cartwright, Ranford-Cartwright Lisa C, Harry P De Koning, De Koning, H.P., de Koning Harry P, Quashie Neils B, Quashie, N.B., Ranford-Cartwright, L.C.   +8 more
core   +1 more source

Comprehensive measurement of purines in biological samples

Frontiers in Analytical Science
Defects in numerous aspects of purine metabolism are well-recognized causes for human diseases. The applicability of ultra performance liquid chromatography (UPLC) with photodiode array (PDA) detection for analysis of the most abundant biological ...
Rong Fu, Diane J. Sutcliffe, Ashok R. Dinasarapu, Ellen J. Hess, Ellen J. Hess, H. A. Jinnah, H. A. Jinnah   +6 more
doaj   +1 more source

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

bioRxiv, 2020
This year nearly 20,000 lives will be lost to Glioblastoma (GBM), a treatment-resistant primary brain cancer. In this study, we identified a molecular circuit driven by epigenetic regulation that regulates the expression of ciliary protein ALR13B.
Jack M. Shireman, Fatemeh Atashi, Gina Lee, Eunus S. Ali, Miranda R. Saathoff, Cheol Park, S. Baisiwala, J. Miska, M. Lesniak, J. David, R. Stupp, P. Kumthekar, C. Horbinski, I. Ben-Sahra, Atique U. Ahmed   +14 more
semanticscholar   +1 more source

ERK2 phosphorylates PFAS to mediate posttranslational control of de novo purine synthesis

Molecules and Cells, 2020
SUMMARY The RAS-ERK/MAPK (RAS-extracellular signal-regulated kinase/mitogen-activated protein kinase) pathway integrates growth-promoting signals to stimulate cell growth and proliferation, at least in part, through alterations in metabolic gene ...
Eunus S. Ali, Umakant Sahu, E. Villa, Brendan P. O’Hara, Peng Gao, Cynthia Beaudet, Antony W. Wood, J. Asara, I. Ben-Sahra   +8 more
semanticscholar   +1 more source

De Novo Purine Biosynthesis Is Required for Intracellular Growth of Staphylococcus aureus and for the Hypervirulence Phenotype of a purR Mutant

Infection and Immunity, 2020
Staphylococcus aureus is a noted human and animal pathogen. Despite decades of research on this important bacterium, there are still many unanswered questions regarding the pathogenic mechanisms it uses to infect the mammalian host.
Mariya I. Goncheva, Ronald S. Flannagan, D. Heinrichs   +2 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

ToshkaDev/Purine-pyrimidine_motif: V1.0.0

<p>Purine receptor project data and code.</p ...
Vadim Gumerov
core   +2 more sources