Results 31 to 40 of about 245,344 (350)
mBio, 2023 Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng +2 more
doaj +1 more source
Ferrocenoyl-adenines: substituent effects on regioselective acylation
Beilstein Journal of Organic Chemistry, 2022 A series of N6-substituted adenine–ferrocene conjugates was prepared and the reaction mechanism underlying the synthesis was explored. The SN2-like reaction between ferrocenoyl chloride and adenine anions is a regioselective process in which the product ...
Mateja Toma +5 more
doaj +1 more source
Frontiers in Nutrition, 2023 The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li +5 more
doaj +1 more source
The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto +3 more
semanticscholar +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert +5 more
core +1 more source
Frontiers in Pharmacology, 2022 Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang +6 more
doaj +1 more source
Nature Communications, 2021 Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals and conceivably compete for space and nutrients. Here, we report that a coagulase-negative staphylococcus, Staphylococcus chromogenes ATCC43764, synthesizes and
Denny Chin +6 more
semanticscholar +1 more source
bioRxiv, 2021 Intestinal epithelial cells are subject to attack by a diverse array of microbes, including intracellular as well as extracellular pathogens. While defense in epithelial cells can be triggered by pattern recognition receptor-mediated detection of microbe-
Eillen Tecle +5 more
semanticscholar +1 more source
Human de novo Purine Biosynthesis
Critical reviews in biochemistry and molecular biology, 2020 The focus of this review is the human de novo purine biosynthetic pathway. The pathway enzymes are enumerated, as well as the reactions they catalyze and their physical properties. Early literature evidence suggested that they might assemble into a multi-
V. Pareek +2 more
semanticscholar +1 more source
Evolutionary Trends in RNA Base Selectivity Within the RNase A Superfamily
Frontiers in Pharmacology, 2019 There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host ...
Guillem Prats-Ejarque +4 more
doaj +1 more source