Results 11 to 20 of about 134,014 (261)
From Gut Homeostasis to Colorectal Cancer: Spatial and Temporal Reprogramming of Microbial Inosine Signaling [PDF]
BiomedicinesMicrobial metabolites are increasingly recognized as critical regulators of gut homeostasis, mediating the interaction among gut microbiota, host tissue, and immune response.
Lorenzo Tomassini +4 more
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Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Yulong Yin, Tiejun Li, Wenkai Ren
exaly +3 more sources
Purine-Furan and Purine-Thiophene Conjugates [PDF]
Molbank, 2018 Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds.
Zigfrīds Kapilinskis +2 more
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Protonated pyrimidine-purine-purine triplex [PDF]
Nucleic Acids Research, 1993 We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
Vladislav A. Malkov +6 more
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Molecules, 2023 Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov +9 more
doaj +1 more source
The interaction of aflatoxins with purines and purine nucleosides [PDF]
Biochemical Journal, 1967 From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino ...
J I, Clifford, K R, Rees
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Frontiers in Veterinary Science, 2023 The objective was to compare and analyze the relationship between growth, purine content, uric acid, and superoxide dismutase (SOD) in purebred and crossbred Thai native chickens. A total of 300 Thai native chickens were divided into 3 groups.
Veeraya Tantiyasawasdikul +6 more
doaj +1 more source
The influence of the addition of polymers on the physico-chemical properties of bentonite suspensions [PDF]
Science of Sintering, 2014 Bentonite clays have many applications in industries ranging from construction to cosmetics. Addition of polymers can profoundly influence the properties of bentonite suspensions and we now describe the influence of a range of different polymers.
Stojiljkovic S. +7 more
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Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
eLife, 2020 Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
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mBio, 2023 Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng +2 more
doaj +1 more source