Results 11 to 20 of about 245,344 (350)
Gut bacterial metabolism contributes to host global purine homeostasis
Cell Host and Microbe, 2023 SUMMARY The microbes and microbial pathways that influence host inflammatory disease progression remain largely undefined. Here we show that variation in atherosclerosis burden is partially driven by gut microbiota and is associated with circulating ...
Aldons Jake Lusis +2 more
exaly +2 more sources
Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
doaj +2 more sources
De novo and salvage purine synthesis pathways across tissues and tumors
CellSUMMARY Purine nucleotides are vital for RNA and DNA synthesis, signaling, metabolism, and energy homeostasis. To synthesize purines, cells use two principal routes: the de novo and salvage pathways. Traditionally, it is believed that proliferating cells
Gerta Hoxhaj, Salma Merchant
exaly +2 more sources
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
Cell, 2020 M. Zaeem Cader1,2,8, Rodrigo Pereira de Almeida Rodrigues1,2,8, James A. West1,2,3,8, Gavin W. Sewell1,2, Muhammad N. Md-Ibrahim1,2, Stephanie Reikine1,4, Giuseppe Sirago1,2, Lukas W.
James Lee +2 more
exaly +2 more sources
Electron transport chain inhibition increases cellular dependence on purine transport and salvage
Cell MetabolismSUMMARY Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders and ...
Ralph J DeBerardinis, Lauren G Zacharias
exaly +2 more sources
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence [PDF]
MicrobiologyOpenBacterial pathogens rely on the constant availability of purine and pyrimidine nucleotides to facilitate replication, growth, and virulence and to sustain energy metabolism and nucleotide‐based signaling.
Riya Joshi +2 more
doaj +2 more sources
Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential
International Journal of Molecular Sciences, 2023 Purines, such as adenine and guanine, perform several important functions in the cell. They are found in nucleic acids; are structural components of some coenzymes, including NADH and coenzyme A; and have a crucial role in the modulation of energy ...
A. Cicero +5 more
semanticscholar +1 more source
Protonated pyrimidine-purine-purine triplex [PDF]
Nucleic Acids Research, 1993 We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
Vladislav A. Malkov +6 more
openaire +3 more sources
Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jing-Chun Liu +7 more
semanticscholar +1 more source
Molecules, 2023 Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov +9 more
doaj +1 more source