Results 71 to 80 of about 245,344 (350)

Efficient Synthesis of α-Branched Purine-Based Acyclic Nucleosides: Scopes and Limitations of the Method

Molecules, 2020
An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride ...
Jan Frydrych, Lenka Poštová Slavětínská, Martin Dračínský, Zlatko Janeba   +3 more
doaj   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Regulating uric acid

eLife
Certain strains of a bacterium found in the gut of some animals, Lactobacillus plantarum, are able to counter hyperuricemia, a condition caused by high levels of uric acid in the blood.
Caihong Hu
doaj   +1 more source

Influência do nitrogênio degradável no rúmen sobre a degradabilidade in situ, os parâmetros ruminais e a eficiência de síntese microbiana em novilhos alimentados com cana-de-açúcar Ruminal degradable nitrogen for steers fed sugar cane: in situ degradability, ruminal parameters and microbial synthesis efficiency

Revista Brasileira de Zootecnia, 2009
Objetivou-se avaliar o efeito da deficiência de nitrogênio degradável no rúmen (NDR), utilizando como volumoso cana-de-açúcar suplementada com uréia, farelo de soja ou farelo de glúten de milho - 60, sobre a eficiência de síntese microbiana e a ...
Roselene Nunes da Silveira, Telma Teresinha Berchielli, Roberta Carrilho Canesin, Juliana Duarte Messana, Juliano José de Resende Fernandes, Alexandre Vaz Pires   +5 more
doaj   +1 more source

The Key Role of Purine Metabolism in the Folate-Dependent Phenotype of Autism Spectrum Disorders: An In Silico Analysis

Metabolites, 2020
Folate deficiency in the critical developmental period has been repeatedly associated with an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological mechanism has not yet been identified. In this work, we focused on identifying
Jan Geryk, Daniel Krsička, Markéta Vlčková, Markéta Havlovicová, Milan Macek, Radka Kremlíková Pourová   +5 more
doaj   +1 more source

Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF^V600E

Pharmaceuticals, 2023
The investigation of novel EGFR and BRAFV600E dual inhibitors is intended to serve as targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed and synthesized as EGFR/BRAFV600E dual inhibitors. The majority of the compounds
Samar A. El-Kalyoubi, Hesham A. M. Gomaa, Elshimaa M. N. Abdelhafez, Mohamed Ramadan, Fatimah Agili, Bahaa G. M. Youssif   +5 more
doaj   +1 more source

A New View into the Regulation of Purine Metabolism – The Purinosome

TIBS -Trends in Biochemical Sciences. Regular ed, 2016
Other than serving as building blocks for DNA and RNA, purines metabolites provide a cell with the necessary energy and cofactors to promote cell survival and proliferation.
Anthony M. Pedley, S. Benkovic
semanticscholar   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Biological Characteristics of a Probiotic Wickerhamomyces anomalus Isolated from Pickled Vegetables and Its Function in Preventing Hyperuricemia in Mice

Foods
Hyperuricemia (HUA) is a metabolic disorder that can easily lead to gout or kidney disease, and it is believed that it can be treated effectively using probiotics.
Xiqian Tan, Shuaibo Gao, Xiaoxiao Cheng, Lijun You, Xuepeng Li, Jianrong Li   +5 more
doaj   +1 more source

Digging into biochemical and signal transduction of old drugs: xanthines and their association to cancer [PDF]

ERU Research Journal
The arena of anticancer drug research has identified xanthine derivatives as intriguing molecules with diverse antimutagenic capabilities against a variety of cancer disorders.
Abdalla Mohamed
doaj   +1 more source