Results 91 to 100 of about 245,344 (350)

Rules governing the genetic code degeneracy/redundancy and spatial organization of the codon informative properties

Frontiers in Applied Mathematics and Statistics
The present study is devoted to describing the “logic” implicit in the standard genetic code. Bases are considered as physicochemical entities possessing two essential properties: molecular type and number of Hydrogen bonds involved (bases pairing) in ...
Melina Rapacioli, Melina Rapacioli, Ricardo Katz, Vladimir Flores, Vladimir Flores   +4 more
doaj   +1 more source

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Nature Neuroscience, 2017
Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands.
Xiu-Xing Wang, Kai-Lin Yang, Qi Xie, Qiu-Lian Wu, S. Mack, Yu Shi, Leo J. Y. Kim, B. Prager, William A. Flavahan, Xiao-Jing Liu, Meromit Singer, C. Hubert, Tyler E. Miller, Wenchao Zhou, Zhi Huang, Xiao-Guang Fang, A. Regev, M. Suvà, T. Hwang, J. Locasale, S. Bao, J. Rich   +21 more
semanticscholar   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Science Translational Medicine, 2017
Saccharomyces cerevisiae induces purine metabolism in mouse intestinal epithelia, resulting in an exacerbation of colitis. Fungi and inflammatory bowel disease Crohn’s disease is associated with an increase in antibodies against the yeast Saccharomyces ...
T. Chiaro, Raymond Soto, W. Stephens, J. Kubinak, Charisse Petersen, L. Gogokhia, Rickesha S. Bell, Julio C. Delgado, James Cox, W. Voth, Jessica C. S. Brown, D. Stillman, R. O'Connell, A. Tebo, J. Round   +14 more
semanticscholar   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus.
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, H. Laakso, N. Friedrich, Julienne C. Kaiser, D. Watson, C. Wilson, J. Sheldon, M. McGavin, P. Kiser, D. Heinrichs   +11 more
semanticscholar   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

The mTORC1 signaling network senses changes in cellular purine nucleotide levels

Cell Reports, 2017
mTORC1 integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid and nucleic acid synthesis. We find that the mTORC1 pathway is responsive to changes in purine nucleotides in a manner analogous to ...
Gerta Hoxhaj, J. Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, J. Asara, I. Ben-Sahra, B. Manning   +7 more
semanticscholar   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

The Safeguarding Microglia: Central Role for P2Y12 Receptors

Frontiers in Pharmacology, 2021
Si-Si Lin, Si-Si Lin, Yong Tang, Yong Tang, Peter Illes, Peter Illes, Peter Illes, Alexei Verkhratsky, Alexei Verkhratsky, Alexei Verkhratsky   +9 more
doaj   +1 more source