Results 101 to 110 of about 157,697 (307)
, 2004 Inelastic Neutron Scattering spectrum of Purine, C₅H₄N₄, measured on the TOSCA ...
S.F. Parker, ISIS Facility
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven +6 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages
Applied SciencesCyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation.
Simona Todisco +8 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Synthesis and Properties of Triazolyl Purine Nucleosides
A novel class of bis-triazolyl purine nucleosides was obtained and triazolyl moiety at C(6) of the purine base undergoes a facile nucleophilic heteroaromatic substitution with N- and S-nucleophiles.
Novosjolova, Irina
core
Levels of purine metabolites and purine synthesis genes.
, 2015 (A) Expression of genes encoding enzymes involved in de novo purine synthesis is negatively correlated to intracellular purine levels. Each point represents the average of the log-transformed, mean-centered and normalized gene expression in purine ...
Olga R. Ilkayeva (42420) +3 more
core +1 more source
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source
Gene Expression Analysis of HPRT-Deficient Cells Maintained with Physiological Levels of Folic Acid
CellsLesch–Nyhan disease (LND) is associated with a complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity due to mutations in the HPRT1 gene.
Rosa J. Torres +4 more
doaj +1 more source
A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates
Biotechnology and Bioengineering, EarlyView.Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm +3 more
wiley +1 more source